Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2021.1887171
Abstract: Abstract A small library of coumarin and their psoralen analogues EMAC10157a-b-d-g and EMAC10160a-b-d-g has been designed and synthesised to investigate the effect of structural modifications on their inhibition ability and selectivity profile towards carbonic anhydrase… read more here.
Keywords: coumarin psoralen; psoralen derivatives; carbonic anhydrase;
Synthesis, anti-acetylcholinesterase evaluation, molecular docking and molecular dynamics simulation of novel Psoralen derivatives.
Sign Up to like & getrecommendations! Published in 2023 at "Current organic synthesis"
DOI: 10.2174/1570179420666230328121554
Abstract: INTRODUCTION Seven new psoralen derivatives were synthesised by carbodiimide coupling to active carboxylic acid to amide formation in mild reaction conditions. METHODS The psoralen derivatives were produced through the condensation of seven different types of… read more here.
Keywords: molecular docking; evaluation; molecular dynamics; psoralen derivatives ... See more keywords
Mechanistic Insights into the Ameliorating Effect of Melanogenesis of Psoralen Derivatives in B16F10 Melanoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27092613
Abstract: The objectives of this study were to investigate the melanogenetic potential of the psoralen derivatives 5-hydroxypsoralen, 5-methoxypsoralen, 8-hydroxypsoralen, 8-methoxypsoralen, and 5,8-dimethoxypsoralen in B16F10 melanoma cells. The results indicated that melanin production is significantly stimulated in… read more here.
Keywords: psoralen derivatives; catenin; melanoma cells; b16f10 melanoma ... See more keywords