Transcriptomics and metabolomics reveal the role of CYP1A2 in psoralen/isopsoralen‐induced metabolic activation and hepatotoxicity
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DOI: 10.1002/ptr.7604
Abstract: Psoralen and isopsoralen are the pharmacologically important but hepatotoxic components in Psoraleae Fructus. The purpose of this study was to reveal the underlying mechanism of psoralen/isopsoralen‐induced hepatotoxicity. Initially, we applied integrated analyses of transcriptomic and… read more here.
Keywords: isopsoralen induced; psoralen isopsoralen; role cyp1a2; metabolic activation ... See more keywords