A monocyte-keratinocyte-derived co-culture assay accurately identifies efficacies of BET inhibitors as therapeutic candidates for psoriasiform dermatitis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2020.08.005
Abstract: BACKGROUND Bromodomain and extra-terminal (BET) proteins perform key roles in epigenetic control of gene expression that is involved in inflammatory conditions, including psoriasiform dermatitis (PsD). Predicting which (of many potential available BET inhibitors) will be… read more here.
Keywords: psoriasiform dermatitis; bet; bet inhibitors; monocyte keratinocyte ... See more keywords
Fingolimod ameliorates imiquimod-induced psoriasiform dermatitis by sequestrating interleukin-17-producing γδ T cells in secondary lymph nodes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2021.04.004
Abstract: BACKGROUND Psoriasis is a chronic inflammatory skin disease. Interleukin (IL)-17A plays a key role in the pathogenesis of psoriasis. Fingolimod, which is available for the treatment of multiple sclerosis, exerts anti-inflammatory effects by sequestrating inflammatory… read more here.
Keywords: psoriasis; psoriasiform dermatitis; lymph nodes; fingolimod ... See more keywords
Apremilast downregulates interleukin-17 production and induces splenic regulatory B cells and regulatory T cells in imiquimod-induced psoriasiform dermatitis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2021.08.001
Abstract: BACKGROUND Apremilast, a selective inhibitor of the enzyme phosphodiesterase 4, is efficacious for psoriasis. However, detailed in vivo effects of apremilast on psoriasis remain to be elucidated. OBJECTIVE To examine the in vivo effects of… read more here.
Keywords: cells regulatory; induced psoriasiform; psoriasiform dermatitis; regulatory cells ... See more keywords
Electrophilic nitro-fatty acids suppress psoriasiform dermatitis: STAT3 inhibition as a contributory mechanism
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.101987
Abstract: Psoriasis is a chronic inflammatory skin disease with no cure. Although the origin of psoriasis and its underlying pathophysiology remain incompletely understood, inflammation is a central mediator of disease progression. In this regard, electrophilic nitro-fatty… read more here.
Keywords: electrophilic nitro; psoriasiform; fatty acids; psoriasiform dermatitis ... See more keywords
Pigmented purpura masquerading as acral melanoma
Sign Up to like & getrecommendations! Published in 2019 at "Australasian Journal of Dermatology"
DOI: 10.1111/ajd.12885
Abstract: were observed (Fig. 2a). Neutrophils were also found in the epidermis. Inflammatory cells mostly consisted of lymphocytes and eosinophils (Fig. 2b). We diagnosed the cutaneous eruption as an eczematous reactions mimicking psoriasiform dermatitis. She responded… read more here.
Keywords: purpura masquerading; masquerading acral; pigmented purpura; psoriasiform dermatitis ... See more keywords
The genetic difference between C57Bl/6J and C57Bl/6N mice significantly impacts Aldara™‐induced psoriasiform dermatitis
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Dermatology"
DOI: 10.1111/exd.13131
Abstract: Since its first description in 2009,1 the AldaraTM (MEDA Pharma GmbH, Bad Homburg, Germany)-induced psoriasiform dermatitis (AIPD) model has become a most commonly used mouse model of plaque psoriasis. It is mostly conducted in the… read more here.
Keywords: c57bl c57bl; c57bl mice; psoriasiform dermatitis; induced psoriasiform ... See more keywords
Topical Treatment of Colquhounia Root Relieves Skin Inflammation and Itch in Imiquimod-Induced Psoriasiform Dermatitis in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Mediators of Inflammation"
DOI: 10.1155/2022/5782922
Abstract: Itch is one of the major clinical manifestations of psoriasis, which is closely related with neurogenic inflammation and difficult to control. Colquhounia Root (CR) is a Chinese herb exhibiting broad bioactivities on anti-inflammation. This study… read more here.
Keywords: induced psoriasiform; psoriasiform dermatitis; imiquimod induced; colquhounia root ... See more keywords
Tofacitinib for the Treatment of Psoriasiform Dermatitis Caused by IL-17 Inhibitors: A Case Report
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s412418
Abstract: Abstract Psoriasis is a recurring systemic disease that can be treated with biologics to some effect. However, precisely targeting inflammatory mediators may disrupt immune system homeostasis and lead to new conditions. Here, we report a… read more here.
Keywords: psoriasiform dermatitis; caused inhibitors; report; case report ... See more keywords
Systemic Psoriasiform Dermatitis Appeared after the Administration of Pembrolizumab
Sign Up to like & getrecommendations! Published in 2019 at "Internal Medicine"
DOI: 10.2169/internalmedicine.3694-19
Abstract: A 78-year-old woman was diagnosed with stage IV A left lower lobe adenocarcinoma by chest computed tomography. There was no history of psoriasis. Her tumor proportion score on PD-L1 was 55%, and she was given… read more here.
Keywords: administration; psoriasiform; dermatitis appeared; psoriasiform dermatitis ... See more keywords