Promoter Methylation Leads to Decreased ZFP36 Expression and Deregulated NLRP3 Inflammasome Activation in Psoriatic Fibroblasts
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DOI: 10.3389/fmed.2020.579383
Abstract: The mRNA-destabilizing protein tristetraprolin (TTP), encoded by the ZFP36 gene, is known to be able to end inflammatory responses by directly targeting and destabilizing mRNAs encoding pro-inflammatory cytokines. We analyzed its role in psoriasis, a… read more here.
Keywords: inflammasome activation; zfp36; psoriatic fibroblasts; expression ... See more keywords