Protection elicited by nasal immunization with pneumococcal surface protein A (PspA) adjuvanted with bacterium-like particles against Streptococcus pneumoniae infection in mice.
Sign Up to like & getrecommendations! Published in 2018 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2018.06.041
Abstract: Streptococcus pneumoniae is a major respiratory tract pathogen causing high levels of mortality and morbidity in infants and the elderly. In spite of the multitude of capsular polysaccharide vaccines used to guard against pneumococcal disease,… read more here.
Keywords: infection; immunization; surface protein; pspa ... See more keywords
PspA facilitates evasion of pneumococci from bactericidal activity of neutrophil extracellular traps (NETs).
Sign Up to like & getrecommendations! Published in 2019 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2019.103653
Abstract: Pneumococcal strains are variably resistant to killing by neutrophil extracellular traps (NETs). We hypothesize that this variability in resistance is due to heterogeneity in pneumococcal surface protein A (PspA), a structurally diverse virulence factor of… read more here.
Keywords: neutrophil extracellular; pspa; killing nets; pneumococcal strains ... See more keywords
Characterization and Specification of a Trivalent Protein-Based Pneumococcal Vaccine Formulation Using an Adjuvant-Free Nanogel Nasal Delivery System.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.0c01003
Abstract: We previously developed a safe and effective nasal vaccine delivery system using a self-assembled nanosized hydrogel (nanogel) made from a cationic cholesteryl pullulan. Here, we generated three pneumococcal surface protein A (PspA) fusion antigens as… read more here.
Keywords: nanogel pspa; pspa; formulation; spectroscopy ... See more keywords
Pneumococcal surface protein A (PspA) prevents killing of Streptococcus pneumoniae by indolicidin
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-73564-9
Abstract: Pneumococcal surface protein A (PspA) is an important virulence factor in Streptococcus pneumoniae that binds to lactoferrin and protects the bacterium from the bactericidal action of lactoferricins—cationic peptides released upon lactoferrin proteolysis. The present study… read more here.
Keywords: indolicidin; pspa; pneumococcal surface; surface protein ... See more keywords
A Novel PspA Protein Vaccine Intranasal Delivered by Bacterium-Like Particles Provides Broad Protection Against Pneumococcal Pneumonia in Mice
Sign Up to like & getrecommendations! Published in 2018 at "Immunological Investigations"
DOI: 10.1080/08820139.2018.1439505
Abstract: ABSTRACT Background: Streptococcus pneumoniae is a major pathogen accounting for a large number of pneumococcal disease in worldwide. Due to the mucosal immune pathway induces both systemic and mucosal immune responses, the potential strategy to… read more here.
Keywords: protein; protein vaccine; pspa; mucosal ... See more keywords
The bacterial ESCRT-III PspA rods thin lipid tubules and increase membrane curvature through helix α0 interactions
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1101/2025.06.13.659447
Abstract: The phage shock protein A (PspA), a bacterial member of the ESCRT-III superfamily, forms rod-shaped helical assemblies that internalize membrane tubules. The N-terminal helix α0 of PspA (and other ESCRT-III members) has been suggested to… read more here.
Keywords: pspa; escrt iii; membrane; terminal helix ... See more keywords
Peripheral spondyloarthritis: a neglected entity—state of the art
Sign Up to like & getrecommendations! Published in 2020 at "RMD Open"
DOI: 10.1136/rmdopen-2019-001136
Abstract: Peripheral spondyloarthritis (pSpA) refers to a number of seemingly different spondyloarthritis subsets in which psoriatic arthritis (PsA) is the most common, and symptoms of arthritis, enthesitis or dactylitis predominate the clinical presentation. Although formal classification… read more here.
Keywords: spondyloarthritis neglected; spondyloarthritis; pspa; neglected entity ... See more keywords
Genetic diversity of pneumococcal surface protein A in invasive pneumococcal isolates from Korean children, 1991-2016
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0183968
Abstract: Pneumococcal surface protein A (PspA) is an important virulence factor of pneumococci and has been investigated as a primary component of a capsular serotype-independent pneumococcal vaccine. Thus, we sought to determine the genetic diversity of… read more here.
Keywords: pneumococcal surface; pneumococcal isolates; genetic diversity; pspa ... See more keywords
Maternal immunization with pneumococcal surface protein A provides the immune memories of offspring against pneumococcal infection
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1059603
Abstract: Introduction Streptococcus pneumoniae (S. pneumoniae) is one of the most widespread pathogens in the world and one of the largest infectious causes of infant mortality. Although current vaccines have various benefits, antibiotic resistance and the… read more here.
Keywords: immunization; pspa; infection; maternal immunization ... See more keywords
Pneumococcal Surface Protein A-Hybrid Nanoparticles Protect Mice from Lethal Challenge after Mucosal Immunization Targeting the Lungs
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14061238
Abstract: Pneumococcal disease remains a global burden, with current conjugated vaccines offering protection against the common serotype strains. However, there are over 100 serotype strains, and serotype replacement is now being observed, which reduces the effectiveness… read more here.
Keywords: mucosal immunization; pspa; hcl; mice lethal ... See more keywords