Nuclear receptor 4A1 (NR4A1) antagonists target paraspeckle component 1 (PSPC1) in cancer cells.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular carcinogenesis"
DOI: 10.1002/mc.23362
Abstract: Paraspeckles compound 1 (PSPC1) is a multifunctional protein that plays an important role in cancer cells, where PSPC1 is a master regulator of pro-oncogenic responses that includes activation of TGFβ (TGFβ1), TGFβ-dependent EMT, and metastasis. The… read more here.
Keywords: receptor 4a1; nr4a1 antagonists; nuclear receptor; pspc1 ... See more keywords
PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13665-6
Abstract: Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide due to metastasis. Paraspeckle component 1 (PSPC1) upregulation has been identified as an HCC pro-metastatic activator associated with poor patient prognosis, but with a… read more here.
Keywords: metastasis; pspc1 ptk6; ptk6 catenin; pspc1 ... See more keywords