Sex, hormones, and genotype interact to influence psychiatric disease, treatment, and behavioral research
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.23872
Abstract: Sex differences exist in the vulnerability, incidence, manifestation, and treatment of numerous neurological and psychiatric diseases. Despite this observation prominent in the literature, little consideration has been given to possible sex differences in outcome in… read more here.
Keywords: research; psychiatric disease; treatment; sex differences ... See more keywords
Mental health dished up—the use of iPSC models in neuropsychiatric research
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-020-02197-9
Abstract: Genetic and molecular mechanisms that play a causal role in mental illnesses are challenging to elucidate, particularly as there is a lack of relevant in vitro and in vivo models. However, the advent of induced… read more here.
Keywords: use; psychiatric disease; disorder; ipsc ... See more keywords
Lmtk3-KO Mice Display a Range of Behavioral Abnormalities and Have an Impairment in GluA1 Trafficking
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.06.033
Abstract: Accumulating evidence suggests that glutamatergic signaling and synaptic plasticity underlie one of a number of ways psychiatric disorders appear. The present study reveals a possible mechanism by which this occurs, through highlighting the importance of… read more here.
Keywords: psychiatric disease; glua1 trafficking; mice display; lmtk3 mice ... See more keywords
A psychiatric disease-related circular RNA controls synaptic gene expression and cognition
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-0653-4
Abstract: Although circular RNAs (circRNAs) are enriched in the mammalian brain, very little is known about their potential involvement in brain function and psychiatric disease. Here, we show that circHomer1a , a neuronal-enriched circRNA abundantly expressed… read more here.
Keywords: cortex; psychiatric disease; gene expression; disease ... See more keywords
Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Psychiatry"
DOI: 10.1038/s41380-021-01273-0
Abstract: Dopaminergic neurons are critical to movement, mood, addiction, and stress. Current techniques for generating dopaminergic neurons from human induced pluripotent stem cells (hiPSCs) yield heterogenous cell populations with variable purity and inconsistent reproducibility between donors,… read more here.
Keywords: subtype specific; psychiatric disease; dopaminergic neurons; neuronal subtype ... See more keywords
Neuroimmunology and neuroinflammation in autoimmune, neurodegenerative and psychiatric disease
Sign Up to like & getrecommendations! Published in 2018 at "Immunology"
DOI: 10.1111/imm.12943
Abstract: An ever‐increasing collection of neurological human diseases are becoming appreciated as encompassing a strong immunological component in pathogenesis or regulation. This derives to a large extent from genome‐wide association studies that have highlighted association with… read more here.
Keywords: neurodegenerative psychiatric; neuroimmunology neuroinflammation; psychiatric disease; disease ... See more keywords
Comorbid Psychiatric Disease Is Associated With Lower Rates of Thrombolysis in Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2018 at "Stroke"
DOI: 10.1161/strokeaha.117.020295
Abstract: Background and Purpose— Intravenous thrombolysis (IVT) improves outcomes after acute ischemic stroke but is underused in certain patient populations. Mental illness is pervasive in the United States, and patients with comorbid psychiatric disease experience inequities… read more here.
Keywords: comorbid psychiatric; ischemic stroke; psychiatric disease; disease ... See more keywords
Psychiatric Comorbidities in Patients With Idiopathic Intracranial Hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200548
Abstract: Background and Objectives Psychiatric disease is a frequent comorbidity in idiopathic intracranial hypertension (IIH) and has been associated with a poor subjective outcome. No prospective studies have investigated psychiatric comorbidities in new-onset IIH. Our primary… read more here.
Keywords: iih; psychiatric disease; disease; psychiatric comorbidities ... See more keywords
Immunopsychiatry – Innovative Technology to Characterize Disease Activity in Autoantibody-Associated Psychiatric Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.867229
Abstract: Background Anti-neural autoantibody-associated psychiatric disease is a novel field in immunopsychiatry that has been attracting attention thanks to its potentially positive therapeutic outcome and distinct prognosis compared with non-organic psychiatric disease. This review aims to… read more here.
Keywords: psychiatric disease; disease; autoantibody associated; immunopsychiatry innovative ... See more keywords
Neuronal oscillations: early biomarkers of psychiatric disease?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2022.1038981
Abstract: Our understanding of the environmental and genetic factors contributing to the wide spectrum of neuropsychiatric disorders has significantly increased in recent years. Impairment of neuronal network activity during early development has been suggested as a… read more here.
Keywords: biomarkers psychiatric; early biomarkers; psychiatric disease; oscillations early ... See more keywords