Simple synthesis of ordered platinum-gold nanoparticles with the enhanced catalytic activity for oxygen reduction reaction
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Electroanalytical Chemistry"
DOI: 10.1016/j.jelechem.2019.113707
Abstract: Abstract Pt-Au nanoparticles supported on carbon black (PtAu/CBx) are produced by a facile chemical reduction method and subsequent heat treatment. In this paper, the effects of heat treatment temperature on structure and electrochemical properties are… read more here.
Keywords: reduction; ptau cb600; ptau; simple synthesis ... See more keywords
Pα-syn* mitotoxicity is linked to MAPK activation and involves tau phosphorylation and aggregation at the mitochondria
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.11.015
Abstract: We recently identified a truncated and phosphorylated form of α-synuclein, pα-syn*, as a key neurotoxic α-synuclein species found in cultured neurons, as well as in mouse and Parkinson's disease patients' brains. Small pα-syn* aggregates localize… read more here.
Keywords: syn mitotoxicity; linked mapk; syn; ptau ... See more keywords
Reproductive status impact on tau phosphorylation induced by chronic stress
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Stress"
DOI: 10.1016/j.ynstr.2020.100241
Abstract: Sex and exposure to chronic stress have been identified as risk factors for developing Alzheimer's disease (AD). Although AD has been demonstrated to be more prevalent in females, sex is often overlooked in research studies,… read more here.
Keywords: status; chronic stress; stress; ptau ... See more keywords
Anti-phospho-tau Gene Therapy for Chronic Traumatic Encephalopathy.
Sign Up to like & getrecommendations! Published in 2019 at "Human gene therapy"
DOI: 10.1089/hum.2019.174
Abstract: Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder caused by repetitive trauma to the central nervous system (CNS) suffered by soldiers, contact sport athletes and civilians following accident-related trauma. CTE is a CNS tauopathy,… read more here.
Keywords: traumatic encephalopathy; gene therapy; cns; ptau ... See more keywords
TAU phosphorylation patterns in the rat cerebral cortex after traumatic brain injury and sodium selenate effects: An EpiBioS4Rx Project 2 study.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurotrauma"
DOI: 10.1089/neu.2022.0219
Abstract: Sodium selenate (SS) activates protein phosphatase 2 (PP2A) and reduces phosphorylated TAU (pTAU) and late post-traumatic seizures after lateral fluid percussion injury (LFPI). In EpiBioS4Rx Project 2, a multicenter international study for post-traumatic targets, biomarkers… read more here.
Keywords: sodium selenate; epibios4rx project; pp2a activity; ptau ... See more keywords
Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation-induced pathology
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.05.08.491088
Abstract: Amyloid aggregation of phosphorylated Tau (pTau) into neurofibrillary tangles is closely associated with Alzheimer’s disease (AD). Several molecular chaperones have been reported to bind Tau and impede its pathological aggregation. Recent findings of elevated levels… read more here.
Keywords: specific binding; aggregation; hsp27; ptau ... See more keywords
Tau pathology in Creutzfeldt‐Jakob disease revisited
Sign Up to like & getrecommendations! Published in 2017 at "Brain Pathology"
DOI: 10.1111/bpa.12411
Abstract: Creutzfeldt‐Jakob disease (CJD) is a human prion disease with different etiologies. To determine the spectrum of tau pathologies in CJD, we assessed phospho‐Tau (pTau) immunoreactivities in 75 sporadic CJD cases including an evaluation of the… read more here.
Keywords: tau; tau pathology; disease; pathology ... See more keywords
Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post-mortem motor cortex and cerebrospinal fluid.
Sign Up to like & getrecommendations! Published in 2021 at "Brain pathology"
DOI: 10.1111/bpa.13035
Abstract: Although the molecular mechanisms underlying amyotrophic lateral sclerosis (ALS) are not yet fully understood, several studies report alterations in tau phosphorylation in both sporadic and familial ALS. Recently, we have demonstrated that phosphorylated tau at… read more here.
Keywords: phosphorylation; tau; post mortem; ptau ... See more keywords
An Open Question: Is the A2A Adenosine Receptor a Novel Target for Alzheimer’s Disease Treatment?
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.652455
Abstract: INTRODUCTION Neurocognitive Disorder due to Alzheimer’s Disease: A Brief Overview According to DSM5, the term neurocognitive disorder (NCD) emphasizes that the cause of mental deficit lies in a pathology affecting neuronal circuits. The early clinical… read more here.
Keywords: question; alzheimer disease; neurocognitive disorder; pathology ... See more keywords