EBV‐MIR‐BHRF1‐1 TARGETS P53 GENE: POTENTIAL ROLE IN EPSTEIN‐BARR VIRUS ASSOCIATED CHRONIC LYMPHOCYTIC LEUKEMIA
Sign Up to like & getrecommendations! Published in 2019 at "Hematological Oncology"
DOI: 10.1002/hon.42_2631
Abstract: cell lines and paired ibrutinb resistant patients primary cells. Resistant MEC-1 cell line was cultured in RPMI 1640 without ibrutinib for 48hrs before transfection, siRNA targeting with PTBP1 mRNA and nontargeting siRNA were transfected into… read more here.
Keywords: mcl; cell line; ibrutinib; ptbp1 ... See more keywords
PTBP1 promotes tumorigenesis by regulating apoptosis and cell cycle in colon cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin du cancer"
DOI: 10.1016/j.bulcan.2018.08.013
Abstract: Increased expression of polypyrimidine tract-binding protein 1 (PTBP1) has been observed in human ovarian tumors, glioblastomas, and breast cancer, but its biological roles in tumorigenesis is not fully clear. In the present research, we investigated… read more here.
Keywords: cancer; cell cycle; colon cancer; ptbp1 ... See more keywords
Identification and Characterization of a Minimal Functional Splicing Regulatory Protein, PTBP1.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00664
Abstract: Polypyrimidine tract binding protein 1 (PTBP1) is a well-studied RNA binding protein that serves as an important model for understanding molecular mechanisms underlying alternative splicing regulation. PTBP1 has four RNA binding domains (RBDs) connected via… read more here.
Keywords: minimal functional; ptbp1; protein ptbp1; target ... See more keywords
PTBP1‐targeting microRNAs regulate cancer‐specific energy metabolism through the modulation of PKM1/M2 splicing
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Science"
DOI: 10.1111/cas.14694
Abstract: Understanding of the microRNAs (miRNAs) regulatory system has become indispensable for physiological/oncological research. Tissue and organ specificities are key features of miRNAs that should be accounted for in cancer research. Further, cancer‐specific energy metabolism, referred… read more here.
Keywords: specific energy; cancer specific; ptbp1; cancer ... See more keywords
MiR-506 targets polypyrimidine tract-binding protein 1 to inhibit airway inflammatory response and remodeling via mediating Wnt/β-catenin signaling pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Allergologia et immunopathologia"
DOI: 10.15586/aei.v51i3.676
Abstract: BACKGROUND Airway remodeling, which contributes to the clinical course of childhood asthma, occurs due to airway inflammation and is featured by anomalous biological behaviors of airway smooth muscle cells (ASMCs). microRNA (miRNA) plays an essential… read more here.
Keywords: pathway; wnt catenin; ptbp1; mir 506 ... See more keywords
High expression of PTBP1 promote invasion of colorectal cancer by alternative splicing of cortactin
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15873
Abstract: Polypyrimidine tract-binding protein 1 (PTBP1) involving in almost all steps of mRNA regulation including alternative splicing metabolism during tumorigenesis due to its RNA-binding activity. Initially, we found that high expressed PTBP1 and poor prognosis was… read more here.
Keywords: cortactin; invasion; colorectal cancer; ptbp1 ... See more keywords
circEXOC5 promotes acute lung injury through the PTBP1/Skp2/Runx2 axis to activate autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.26508/lsa.202201468
Abstract: circEXOC5 activates autophagy and promotes acute lung injury via stimulating the Skp2 decay to stabilize Runx2 by interacting with PTBP1. To understand the pathogenesis of acute lung injury (ALI), we focused on circEXOC5, a significantly… read more here.
Keywords: circexoc5; ptbp1; runx2; lung injury ... See more keywords
Neural Isoforms of Agrin Are Generated by Reduced PTBP1−RNA Interaction Network Spanning the Neuron−Specific Splicing Regions in AGRN
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087420
Abstract: Agrin is a heparan sulfate proteoglycan essential for the clustering of acetylcholine receptors at the neuromuscular junction. Neuron−specific isoforms of agrin are generated by alternative inclusion of three exons, called Y, Z8, and Z11 exons,… read more here.
Keywords: neuron specific; rna; ptbp1; isoforms agrin ... See more keywords
Repressing PTBP1 fails to convert reactive astrocytes to dopaminergic neurons in a 6-hydroxydopamine mouse model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.75636
Abstract: Lineage reprogramming of resident glial cells to dopaminergic neurons (DAns) is an attractive prospect of the cell-replacement therapy for Parkinson’s disease (PD). However, it is unclear whether repressing polypyrimidine tract binding protein 1 (PTBP1) could… read more here.
Keywords: reactive astrocytes; parkinson disease; dopaminergic neurons; ptbp1 ... See more keywords