PTBP1 Regulates DNMT3B Alternative Splicing by Interacting With RALY to Enhance the Radioresistance of Prostate Cancer
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202405997
Abstract: Radiotherapy is a curative arsenal for prostate cancer (PCa), but radioresistance seriously compromises its effectiveness. Dysregulated RNA splicing factors are extensively involved in tumor progression. Nonetheless, the role of splicing factors in radioresistance remains largely… read more here.
Keywords: splicing factors; dnmt3b; prostate cancer; pca ... See more keywords
EBV‐MIR‐BHRF1‐1 TARGETS P53 GENE: POTENTIAL ROLE IN EPSTEIN‐BARR VIRUS ASSOCIATED CHRONIC LYMPHOCYTIC LEUKEMIA
Sign Up to like & getrecommendations! Published in 2019 at "Hematological Oncology"
DOI: 10.1002/hon.42_2631
Abstract: cell lines and paired ibrutinb resistant patients primary cells. Resistant MEC-1 cell line was cultured in RPMI 1640 without ibrutinib for 48hrs before transfection, siRNA targeting with PTBP1 mRNA and nontargeting siRNA were transfected into… read more here.
Keywords: mcl; cell line; ibrutinib; ptbp1 ... See more keywords
PTBP1 promotes tumorigenesis by regulating apoptosis and cell cycle in colon cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin du cancer"
DOI: 10.1016/j.bulcan.2018.08.013
Abstract: Increased expression of polypyrimidine tract-binding protein 1 (PTBP1) has been observed in human ovarian tumors, glioblastomas, and breast cancer, but its biological roles in tumorigenesis is not fully clear. In the present research, we investigated… read more here.
Keywords: cancer; cell cycle; colon cancer; ptbp1 ... See more keywords
Identification and Characterization of a Minimal Functional Splicing Regulatory Protein, PTBP1.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00664
Abstract: Polypyrimidine tract binding protein 1 (PTBP1) is a well-studied RNA binding protein that serves as an important model for understanding molecular mechanisms underlying alternative splicing regulation. PTBP1 has four RNA binding domains (RBDs) connected via… read more here.
Keywords: minimal functional; ptbp1; protein ptbp1; target ... See more keywords
SENP1 exacerbates acute myeloid leukemia by enhancing BECN1-dependent autophagy through PTBP1 deSUMOylation.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiae143
Abstract: Genetic association between SUMO-specific protease 1 (SENP1) and acute myeloid leukemia (AML) has been validated. However, the mechanism by which SENP1 affects AML proliferation, apoptosis, and autophagy remains unknown. The levels of SENP1 and polypyrimidine… read more here.
Keywords: acute myeloid; aml; ptbp1; autophagy ... See more keywords
PTBP1‐targeting microRNAs regulate cancer‐specific energy metabolism through the modulation of PKM1/M2 splicing
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Science"
DOI: 10.1111/cas.14694
Abstract: Understanding of the microRNAs (miRNAs) regulatory system has become indispensable for physiological/oncological research. Tissue and organ specificities are key features of miRNAs that should be accounted for in cancer research. Further, cancer‐specific energy metabolism, referred… read more here.
Keywords: specific energy; cancer specific; ptbp1; cancer ... See more keywords
Abstract P5-06-14: PTBP1 is associated with tumor proliferation as an oncogene that regulates breast cancer metabolism
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.sabcs24-p5-06-14
Abstract: Background: We previously studied cancer cell metabolism. A critical difference exists between cancer and normal cells in terms of their energy-producing mechanisms. Polypyrimidine tract-binding protein 1 (PTBP1), which is predominantly expressed in tumor cells, plays… read more here.
Keywords: cancer; tumor; cell; metabolism ... See more keywords
PTBP1, an RNA Binding Protein and Splicing Regulator, Binds RUNX1 and Co-Localizes at Target Gene Promoters in Leukemia
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-205878
Abstract: The transcription factor RUNX1 is a key regulator of both Acute Myeloid and Acute Lymphoid Leukemia. Work by our lab and others has shown that RUNX1 binds Histone Deacetylase 1 (HDAC1) and that the two… read more here.
Keywords: hdac1; runx1; ptbp1; interaction ... See more keywords
Transcriptome analysis reveals PTBP1 as a key regulator of circRNA biogenesis
Sign Up to like & getrecommendations! Published in 2025 at "BMC Biology"
DOI: 10.1186/s12915-025-02233-8
Abstract: Circular RNAs (circRNAs) are a class of non-coding RNAs generated through back splicing. High expression of circRNAs is often associated with numerous abnormal cellular biological processes. However, the regulatory factors of circRNAs are not fully… read more here.
Keywords: regulator circrna; analysis; circrna biogenesis; ptbp1 ... See more keywords
MiR-10b-5p attenuates spinal cord injury and alleviates LPS-induced PC12 cells injury by inhibiting TGF-β1 decay and activating TGF-β1/Smad3 pathway through PTBP1
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Medical Research"
DOI: 10.1186/s40001-024-02133-7
Abstract: Spinal cord injury (SCI) is a debilitating condition characterized by significant sensory, motor, and autonomic dysfunctions, leading to severe physical, psychological, and financial burdens. The current therapeutic approaches for SCI show limited effectiveness, highlighting the… read more here.
Keywords: pc12 cells; spinal cord; mir 10b; smad3 pathway ... See more keywords
MiR-506 targets polypyrimidine tract-binding protein 1 to inhibit airway inflammatory response and remodeling via mediating Wnt/β-catenin signaling pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Allergologia et immunopathologia"
DOI: 10.15586/aei.v51i3.676
Abstract: BACKGROUND Airway remodeling, which contributes to the clinical course of childhood asthma, occurs due to airway inflammation and is featured by anomalous biological behaviors of airway smooth muscle cells (ASMCs). microRNA (miRNA) plays an essential… read more here.
Keywords: pathway; wnt catenin; ptbp1; mir 506 ... See more keywords