Small molecule Y-320 stimulates ribosome biogenesis, protein synthesis, and aminoglycoside-induced premature termination codon readthrough
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DOI: 10.1371/journal.pbio.3001221
Abstract: Premature termination codons (PTC) cause over 10% of genetic disease cases. Some aminoglycosides that bind to the ribosome decoding center can induce PTC readthrough and restore low levels of full-length functional proteins. However, concomitant inhibition… read more here.
Keywords: protein; g418; protein synthesis; ptc readthrough ... See more keywords
Functional Restoration of BRCA1 Nonsense Mutations by Aminoglycoside-Induced Readthrough
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DOI: 10.3389/fphar.2022.935995
Abstract: BRCA1 is a major tumor suppressor that functions in the accurate repair of DNA double-strand breaks via homologous recombination (HR). Nonsense mutations in BRCA1 lead to inactive truncated protein products and are associated with high… read more here.
Keywords: ptc readthrough; brca1; brca1 nonsense; nonsense mutations ... See more keywords