PTC299 Is a Novel DHODH Inhibitor That Modulates VEGFA mRNA Translation and Inhibits Proliferation of a Broad Range of Leukemia Cells
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DOI: 10.1182/blood.v130.suppl_1.1371.1371
Abstract: PTC299 was identified in a phenotypic high through put screen as an inhibitor of VEGFA mRNA translation and had been in clinical development for solid tumors. Here we demonstrate that PTC299 inhibits dihydroorotate dehydrogenase (DHODH),… read more here.
Keywords: ptc therapeutics; therapeutics employment; translation; ptc299 ... See more keywords