Inhibition of De Novo Pyrimidine Nucleotide Synthesis By the Novel DHODH Inhibitor PTC299 Induces Differentiation and/or Death of AML Cells
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DOI: 10.1182/blood-2019-124569
Abstract: Background: Pyrimidine nucleotides are generated either by de novo synthesis or the salvage pathway in which pyrimidine nucleotides are obtained from the diet. Resting cells typically acquire adequate pyrimidine nucleotides from the salvage pathway. Rapidly… read more here.
Keywords: research; pyrimidine; ptc299; research funding ... See more keywords
PTC299 Is a Novel DHODH Inhibitor That Modulates VEGFA mRNA Translation and Inhibits Proliferation of a Broad Range of Leukemia Cells
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DOI: 10.1182/blood.v130.suppl_1.1371.1371
Abstract: PTC299 was identified in a phenotypic high through put screen as an inhibitor of VEGFA mRNA translation and had been in clinical development for solid tumors. Here we demonstrate that PTC299 inhibits dihydroorotate dehydrogenase (DHODH),… read more here.
Keywords: ptc therapeutics; therapeutics employment; translation; ptc299 ... See more keywords