The interplay of Patched, Smoothened and cholesterol in Hedgehog signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2019.06.008
Abstract: The Hedgehog (HH) pathway plays a pivotal role in regulating a diverse array of events from embryonic tissue patterning to adult organ self-renewal. Aberrant activation of the pathway is linked to carcinogenesis. Key factors in… read more here.
Keywords: interplay patched; hedgehog; cholesterol; ptch ... See more keywords
Expression of the hippocampal PTCH during early abstinence is associated with drinking patterns in a rat model of voluntary alcohol intake
Sign Up to like & getrecommendations! Published in 2021 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001646
Abstract: Supplemental Digital Content is available in the text. Perinatal alcohol exposure induces fetal alcohol syndrome partially through Sonic Hedgehog (SHH) impairment; however, the relationship between SHH signaling cascade and alcohol drinking pattern in adulthood remains… read more here.
Keywords: early abstinence; alcohol; drinking; ptch ... See more keywords
Abstract 5271: Inhibition of ultraviolet B radiation-induced mast cell recruitment by silibinin in its efficacy against basal cell carcinoma in Ptch+/− mouse model
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5271
Abstract: Recently, we have reported the chemopreventive and therapeutic efficacy of topical silibinin (SB, a natural flavonolignan from milk thistle seeds) application against ultraviolet B radiation (UVB)-induced basal cell carcinoma (BCC) growth and progression. During the… read more here.
Keywords: cell; bcc; ptch; efficacy ... See more keywords
Hedgehog Signalling Modulates Immune Response and Protects against Experimental Autoimmune Encephalomyelitis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23063171
Abstract: The Hedgehog (Hh) pathway is essential for the embryonic development and homeostatic maintenance of many adult tissues and organs. It has also been associated with some functions of the innate and adaptive immune system. However,… read more here.
Keywords: response; immune response; experimental autoimmune; ptch ... See more keywords