Hematopoietic Cell Transplantation and Adoptive Cell Therapy in Peripheral T Cell Lymphoma
Sign Up to like & getrecommendations! Published in 2020 at "Current Hematologic Malignancy Reports"
DOI: 10.1007/s11899-020-00590-5
Abstract: Purpose of Review Peripheral T cell lymphomas (PTCLs) are a heterogeneous group of diseases and represent approximately 10–15% of all non-Hodgkin lymphomas. Multiagent chemotherapy with a CHOP (cyclophosphamide, adriamycin, vincristine, prednisone)-like regimen is the current… read more here.
Keywords: treatment; ptcl; hematopoietic cell; therapy ... See more keywords
Synthesis, crystal and solution structures of platinacyclic complexes containing eugenol, the main bioactive constituent of Ocimum sanctum L. oil
Sign Up to like & getrecommendations! Published in 2018 at "Polyhedron"
DOI: 10.1016/j.poly.2018.05.055
Abstract: Abstract The dinuclear platinacyclic complex [Pt2Cl2(Eug-1H)2] (1) (Eug-1H = deprotonated eugenol) has been synthesized. Reaction of 1 with amines afforded [PtCl(Eug-1H)(pyridine)] (2), [PtCl(Eug-1H)(4-Me-pyridine)] (3), [PtCl(Eug-1H)(piperidine)] (4), [PtCl(Eug-1H)(quinoline)] (5), [PtCl(Eug-1H)(NH3)] (6), [PtCl(Eug-1H)(4-Me-aniline)] (7), [PtCl(Eug-1H)(4-Cl-aniline)] (8), [Pt(Eug-1H)(8-O-quinoline)] (9) and… read more here.
Keywords: bond; eug quinoline; ptcl; solution ... See more keywords
Crazy paving pattern as a rare radiological manifestation of peripheral T-cell lymphoma (PTCL) with lung involvement: A case report
Sign Up to like & getrecommendations! Published in 2018 at "Respiratory Medicine Case Reports"
DOI: 10.1016/j.rmcr.2018.09.015
Abstract: Abstract We report on a 70-year old woman with dyspnea, systemic lymphadenopathy and abnormal chest computed tomography (CT) findings. A complete laboratory testing as well as mediastinal tissue sampling via Endobronchial Ultrasound (EBUS)-guided Transbronchial Needle… read more here.
Keywords: manifestation; lymphoma; ptcl; lung involvement ... See more keywords
Nivolumab in patients with relapsed or refractory peripheral T-cell lymphoma: modest activity and cases of hyperprogression
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004984
Abstract: Peripheral T-cell lymphomas (PTCL), a heterogeneous group of mature aggressive non-Hodgkin’s lymphomas, carry a worse prognosis for most subtypes when compared with their B-cell counterparts. Despite recent approval of newer therapies, the outlook for patients… read more here.
Keywords: cell; cell lymphoma; peripheral cell; relapsed refractory ... See more keywords
Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma.
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2018-09-872549
Abstract: Peripheral T-cell lymphoma (PTCL) is a group of complex clinicopathological entities, often associated with an aggressive clinical course. Angioimmunoblastic T-cell lymphoma (AITL) and PTCL-not otherwise specified (PTCL-NOS) are the 2 most frequent categories, accounting for… read more here.
Keywords: ptcl gata3; molecular subgroups; ptcl; cell ... See more keywords
Genome-Wide microRNA Expression Profiling in Molecular Subgroups of Peripheral T-Cell Lymphoma Identified Role of Mir-126 in T-Cell Lymphomagenesis
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-129327
Abstract: Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of non-Hodgkin lymphomas and approximately 30% of PTCLs are designated as not-otherwise specified (PTCL-NOS). Gene expression profiling (GEP) identified molecular classifiers for PTCL entities and identified 2… read more here.
Keywords: mirna; mir 126; mir; ptcl ... See more keywords
DNMT3A Mutations Identify a Prognostic Subgroup in Peripheral T-Cell Lymphoma
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DOI: 10.1182/blood-2020-143335
Abstract: Background Mutational profiling of angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) has revealed recurrent mutations in DNMT3A, a de novo methyltransferase. DNMT3A catalyzes the conversion of cytosine to 5-methylcytosine (5-mC)… read more here.
Keywords: ptcl tbx21; cell lymphoma; dnmt3a; cell ... See more keywords
Reproducing the Molecular Subclassification of Peripheral T-cell Lymphoma-NOS by Immunohistochemistry.
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood.2019000779
Abstract: Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of mature T-cell malignancies with approximately one-third of cases designated as PTCL-not otherwise specified (PTCL-NOS). Using gene expression profiling (GEP), we have previously defined two major molecular… read more here.
Keywords: ihc algorithm; ptcl; cell; peripheral cell ... See more keywords
Multicenter Phase 2 Study of Oral azacitidine (CC-486) plus CHOP as initial treatment for peripheral T-cell lymphoma.
Sign Up to like & getrecommendations! Published in 2023 at "Blood"
DOI: 10.1182/blood.2022018254
Abstract: PTCL with T-follicular helper phenotype (PTCL-TFH) has recurrent mutations affecting epigenetic regulators, which may contribute to aberrant DNA methylation and chemoresistance. This phase 2 study evaluated oral azacitidine (CC-486), a DNA methyltransferase inhibitor, plus CHOP… read more here.
Keywords: ptcl tfh; oral azacitidine; ptcl; phase study ... See more keywords
An objective based model of published treatment options for relapsed or refractory (R/R) peripheral t-cell lymphoma (PTCL): An evidence-based decision-making approach.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e19048
Abstract: e19048 Background: PTCL are rare diseases with a poor prognosis. Front line therapy achieves CR in 30% to 60% and OS of 25%. Patients with R/R disease have an even worse prognosis. There is no… read more here.
Keywords: scoring system; pathology; approach; ptcl ... See more keywords
Pralatrexate for Peripheral T-cell lymphoma (PTCL): Chance only supports the prepared mind. Systematic review.
Sign Up to like & getrecommendations! Published in 2022 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520622666220610151603
Abstract: BACKGROUND Due to their primary effects on DNA synthesis, antimetabolites are most effective against actively dividing cells and significantly specific to the cell cycle phase. Pralatrexate (PDX), an antifolate metabolite designed to accumulate in cancer… read more here.
Keywords: cell; cell lymphoma; peripheral cell; ptcl ... See more keywords