Dynamics of Immune Cell Reconstitution in Allogeneic Hematopoietic Cell Transplant Patients Receiving Post-Transplant Cyclophosphamide (PTCy)
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.528
Abstract: In the setting of haploidentical hematopoietic cell transplantation (haplo-HCT), post-transplant cyclophosphamide (PTCy) selectively eliminates alloreactive T cells in-vivo, resulting in favorable graft versus host disease (GVHD), non-relapse mortality (NRM) and relapse outcomes. However, few studies… read more here.
Keywords: hematopoietic cell; transplant; cohort; cell ... See more keywords
Direct Integration of Anti-CD19 Chimeric-Antigen-Receptor (CAR) T Cells Early after Post-Transplantation Cyclophosphamide (PTCy) in Murine MHC-Haploidentical Hematopoietic Cell Transplantation (HCT) Exerts Anti-Tumor Effects without Causing Graft-Versus-Host Disease (GVHD)
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2019.12.032
Abstract: Anti-CD19 CAR T cells can induce remissions in many patients. Yet, relapses can occur and so some patients may proceed to HCT either prior to or after relapse to try to achieve long-term cure. Even… read more here.
Keywords: ptcy; hct; gvhd; car cells ... See more keywords
Incidence and Impact of Community Respiratory Viral Infection (CRV) in Haploidentical and Matched Sibling Donors Receiving Post-Transplant Cyclophosphamide (PTCy): A CIBMTR Analysis
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2019.12.219
Abstract: There are reports of high rates of viral infections after haploidentical transplant, particularly in the setting of PTCy (HaploCy) but detailed data on incidence are lacking. We describe here the comparative incidence of community respiratory… read more here.
Keywords: incidence; ptcy; infection; transplant ... See more keywords
Post-transplantation cyclophosphamide for chimerism-based tolerance
Sign Up to like & getrecommendations! Published in 2019 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-019-0615-0
Abstract: High-dose cyclophosphamide given post-transplant (PTCy) successfully enables tolerance induction in HLA-mismatched related blood or marrow transplantation (haploBMT) manifested by low rates of graft failure, severe acute graft-versus-host disease (GVHD), and chronic GVHD. When proceeded by… read more here.
Keywords: based tolerance; transplantation; chimerism based; ptcy ... See more keywords
PTCy and “The Story of the Three Bears”
Sign Up to like & getrecommendations! Published in 2020 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-020-01123-7
Abstract: In this issue of Bone Marrow Transplantation, Sugita et al. [1] report results of two prospective multicenter studies conducted by the Japan Study Group for Cell Therapy and Transplantation that evaluate the safety and efficacy… read more here.
Keywords: use; ptcy; transplant; transplantation ... See more keywords
Reduced dose of PTCy followed by adjuvant α-galactosylceramide enhances GVL effect without sacrificing GVHD suppression
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-92526-z
Abstract: Posttransplantation cyclophosphamide (PTCy) has become a popular option for haploidentical hematopoietic stem cell transplantation (HSCT). However, personalized methods to adjust immune intensity after PTCy for each patient’s condition have not been well studied. Here, we… read more here.
Keywords: reduced dose; ptcy; dose ptcy; gvl effect ... See more keywords
Low-dose post-transplant cyclophosphamide can mitigate GVHD and enhance the G-CSF/ATG induced GVHD protective activity and improve haploidentical transplant outcomes
Sign Up to like & getrecommendations! Published in 2017 at "OncoImmunology"
DOI: 10.1080/2162402x.2017.1356152
Abstract: ABSTRACT Use of high-dose, post-transplant cyclophosphamide (PTCy) results in low rates of graft-versus-host-disease (GVHD) and favorable immune reconstitution, although with higher rates of relapse and somewhat high rates of graft failure. We hypothesized that permissible… read more here.
Keywords: low dose; ptcy; atg; dose ptcy ... See more keywords
Successful Haploidentical Stem Cell Transplant With Posttransplant Cyclophosphamide in Wiskott-Aldrich Syndrome With Myeloablative Conditioning.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000001841
Abstract: Hematopoietic stem cell transplant (HSCT) is the only curative treatment modality for Wiskott-Aldrich syndrome. Haploidentical HSCT with posttransplant cyclophosphamide (PTCy) is an upcoming option in children with nonmalignant conditions. However, only few cases have been… read more here.
Keywords: aldrich syndrome; myeloablative conditioning; hsct; wiskott aldrich ... See more keywords
Post‐transplant cyclophosphamide limits reactive donor T cells and delays the development of graft‐versus‐host disease in a humanized mouse model
Sign Up to like & getrecommendations! Published in 2021 at "Immunology"
DOI: 10.1111/imm.13374
Abstract: Graft‐versus‐host disease (GVHD) is a major complication of allogeneic haematopoietic stem cell transplantation (allo‐HSCT) that develops when donor T cells in the graft become reactive against the host. Post‐transplant cyclophosphamide (PTCy) is increasingly used in… read more here.
Keywords: ptcy; donor cells; host; mice ... See more keywords
Ptcy + ATG Vs Ptcy Alone As Gvhd Prophylaxis for Peripheral Blood Stem Cells Haplo-Transplants: Comparison of NK and T Cell Effector Reconstitution
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-130822
Abstract: Backgound: A higher incidence of graft-versus-host disease (GVHD) has been observed after haplo-transplant of hematopoietic stem cells with post-transplant cyclophosphamide (PTCY) using peripheral blood stem cells (PBSC) instead of bone marrow as source of graft.… read more here.
Keywords: ptcy; group; reconstitution; ptcy atg ... See more keywords
Incidence, Risk Factors and Outcomes of Cardiac Toxicity in Haploidentical Peripheral Stem Cell Transplantation with High Dose Cyclophosphamide
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-141416
Abstract: Introduction: Haploidentical donor transplant (HIDT) with high dose post-transplant cyclophosphamide (PTcy) has shown promising results in terms of GVHD and survival. PTcy when given on day +3 and +4 is associated with considerable morbidity. In… read more here.
Keywords: stem cell; toxicity; cardiac toxicity; risk factors ... See more keywords