Phosphorylated TDP-43 aggregates in peripheral motor nerves of patients with amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awab285
Abstract: Abstract Phosphorylated TDP-43 (pTDP-43) aggregates in the cytoplasm of motor neurons and neuroglia in the brain are one of the pathological hallmarks of amyotrophic lateral sclerosis. Although the axons exceed the total volume of motor… read more here.
Keywords: lateral sclerosis; patients amyotrophic; ptdp; motor ... See more keywords
TDP-43 and tau concurrence in the entorhinal subfields in primary age-related tauopathy and preclinical Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2023 at "Brain pathology"
DOI: 10.1111/bpa.13159
Abstract: Phosphorylated tau (p-tau) pathology correlates strongly with cognitive decline and is a pathological hallmark of Alzheimer's Disease (AD). In recent years, phosphorylated transactive response DNA-binding protein (pTDP-43) has emerged as a common comorbidity, found in… read more here.
Keywords: tau; primary age; alzheimer disease; pathology ... See more keywords
Phosphorylated TDP-43 localizes to chronic cerebral infarctions in human brains.
Sign Up to like & getrecommendations! Published in 2020 at "Histology and histopathology"
DOI: 10.14670/hh-18-235
Abstract: The transactivation response DNA-binding protein of 43 kDa (TDP-43) is a nuclear protein pivotal in RNA processing. Because phosphorylated TDP43 (pTDP-43) has been identified as a component of the ubiquitin-positive and tau-negative inclusions observed in… read more here.
Keywords: cerebral infarctions; human brains; ptdp; chronic cerebral ... See more keywords