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   Articles with "ptdser" as a keyword



Flippase and scramblase for phosphatidylserine exposure.

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recommendations! Published in 2019 at "Current opinion in immunology"

DOI: 10.1016/j.coi.2019.11.009

Abstract: In various biological processes, phosphatidylserine (PtdSer) that is normally sequestered to the inner leaflet of the plasma membrane (PM) is exposed to the cell surface. When platelets are activated, they expose PtdSer to activate the… read more here.

Keywords: flippase scramblase; phosphatidylserine exposure; scramblase phosphatidylserine; ptdser ... See more keywords

Regulation of phospholipid dynamics in brain

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recommendations! Published in 2021 at "Neuroscience Research"

DOI: 10.1016/j.neures.2021.01.003

Abstract: Phospholipids are asymmetrically distributed at the plasma membrane. Phosphatidylserine (PtdSer) is exclusively located in the inner leaflet of the cell membrane while phosphatidylcholine (PtdCho) and glycolipids are mainly located in the outer leaflet of the… read more here.

Keywords: phospholipid dynamics; ptdser; regulation phospholipid; compartments living ... See more keywords

Requirement of Xk and Vps13a for the P2X7-mediated phospholipid scrambling and cell lysis in mouse T cells

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2119286119

Abstract: Significance The extracellular concentration of adenosine triphosphate (ATP) reaches several hundred micromoles in the inflamed tissues or tumor environment. A high concentration of ATP activates P2X7, a purinergic receptor, and induces the formation of a… read more here.

Keywords: cell lysis; ptdser; p2x7; vps13a ... See more keywords

Targeting plasma membrane phosphatidylserine content to inhibit oncogenic KRAS function

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recommendations! Published in 2019 at "Life Science Alliance"

DOI: 10.26508/lsa.201900431

Abstract: KRAS-dependent cancer cell growth is inhibited by disrupting phosphatidylserine transport to the plasma membrane by genetic knockdown of lipid exchangers ORP5 and ORP8 or by inhibition of PI4KIIIα. The small GTPase KRAS, which is frequently… read more here.

Keywords: ptdser; content; kras function; orp5 orp8 ... See more keywords