Chemopreventive effects of nanoparticle curcumin in a mouse model of Pten-deficient prostate cancer
Sign Up to like & getrecommendations! Published in 2020 at "Human Cell"
DOI: 10.1007/s13577-020-00337-7
Abstract: The present study investigated the antitumor activity and chemopreventive effects of a nanoparticle formulation of curcumin in preclinical models of mouse Pten-deficient prostate cancer. The antitumor activity of the nanoparticle curcumin was evaluated in mouse… read more here.
Keywords: prostate; prostate cancer; nanoparticle curcumin; pten deficient ... See more keywords
ATM inhibition induces synthetic lethality and enhances sensitivity of PTEN‐deficient breast cancer cells to cisplatin
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.03.006
Abstract: ABSTRACT PTEN deficiency often causes defects in DNA damage repair. Currently, effective therapies for breast cancer are lacking. ATM is an attractive target for cancer treatment. Previous studies suggested a synthetic lethality between PTEN and… read more here.
Keywords: cells cisplatin; breast cancer; pten deficient; cancer cells ... See more keywords
Inhibition of polyploidization in Pten‐deficient livers reduces steatosis
Sign Up to like & getrecommendations! Published in 2022 at "Liver International"
DOI: 10.1111/liv.15384
Abstract: The tumour suppressor PTEN is a negative regulator of the PI3K/AKT signalling pathway. Liver‐specific deletion of Pten in mice results in the hyper‐activation PI3K/AKT signalling accompanied by enhanced genome duplication (polyploidization), marked lipid accumulation (steatosis)… read more here.
Keywords: deficient livers; pten deficient; steatosis; polyploidization pten ... See more keywords
Increased T-cell Infiltration Elicited by Erk5 Deletion in a Pten-Deficient Mouse Model of Prostate Carcinogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-16-2565
Abstract: Prostate cancer does not appear to respond to immune checkpoint therapies where T-cell infiltration may be a key limiting factor. Here, we report evidence that ablating the growth regulatory kinase Erk5 can increase T-cell infiltration… read more here.
Keywords: prostate; cell infiltration; pten deficient; cancer ... See more keywords
Targeting the Synthetic Vulnerability of PTEN-Deficient Glioblastoma Cells with MCL1 Inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-20-0099
Abstract: PTEN deletion or mutation occurs in 30% to 60% of patients with glioblastoma (GBM) and is associated with poor prognosis. Efficacious therapy for this subgroup of patients is currently lacking. To identify potential target(s) to… read more here.
Keywords: gbm cells; synthetic vulnerability; pten deficient; targeting synthetic ... See more keywords
RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12113178
Abstract: Simple Summary PTEN is an important tumor suppressor that is frequently mutated in malignancy. PTEN mutational loss has been associated with reduced RAD51 expression and homologous recombination deficiency (HRD), however; recent studies have failed to… read more here.
Keywords: activity; expression; pten deficient; rad51 expression ... See more keywords
ATM Kinase Inhibition Preferentially Sensitises PTEN-Deficient Prostate Tumour Cells to Ionising Radiation
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers13010079
Abstract: Simple Summary Prostate cancer is the most frequently diagnosed cancer in men. Despite the importance of radical radiotherapy for the management of this disease, recurrence remains a challenge. PTEN is a tumour suppressor that is… read more here.
Keywords: prostate; radiotherapy; prostate cancer; pten deficient ... See more keywords