Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair.
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DOI: 10.1016/j.ccell.2019.01.020
Abstract: Ionizing radiation (IR) and chemotherapy are standard-of-care treatments for glioblastoma (GBM) patients and both result in DNA damage, however, the clinical efficacy is limited due to therapeutic resistance. We identified a mechanism of such resistance… read more here.
Keywords: radiation sensitivity; pten tyrosine; dna repair; phosphorylation ... See more keywords