Discovery of Pteridine-7(8H)-one Derivatives as Potent and Selective Inhibitors of Bruton's Tyrosine Kinase (BTK).
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DOI: 10.1021/acs.jmedchem.1c02208
Abstract: Bruton's tyrosine kinase (BTK) is an attractive therapeutic target in the treatment of cancer, inflammation, and autoimmune diseases. Covalent and noncovalent BTK inhibitors have been developed, among which covalent BTK inhibitors have shown great clinical… read more here.
Keywords: one derivatives; tyrosine kinase; kinase btk; pteridine one ... See more keywords