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Published in 2020 at "New Journal of Chemistry"
DOI: 10.1039/d0nj03477k
Abstract: To develop novel simultaneous inhibition of PLK1 and BRD4 bromodomain by a single molecule, three series of novel pteridinone derivatives were designed, synthesized and evaluated for their biological activity. Most compounds exhibited moderate to excellent…
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Keywords:
design synthesis;
cell lines;
plk1 brd4;
pteridinone derivatives ... See more keywords