HMGA1 expression levels are elevated in pancreatic intraepithelial neoplasia cells in the Ptf1a-Cre; LSL-KrasG12D transgenic mouse model of pancreatic cancer
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DOI: 10.1038/bjc.2017.216
Abstract: Background:Pancreatic cancer is currently the third leading cause of cancer deaths in the United States and it is predicted to become the second by the year 2030. High-mobility group A1 protein (HMGA1) is an oncogenic… read more here.
Keywords: ptf1a cre; cre lsl; pancreatic cancer; cancer ... See more keywords
ARID1A Maintains Differentiation of Pancreatic Ductal Cells and Inhibits Development of Pancreatic Ductal Adenocarcinoma in Mice.
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DOI: 10.1053/j.gastro.2018.03.039
Abstract: BACKGROUND & AIMS The ARID1A gene encodes a protein that is part of the large adenosine triphosphate (ATP)-dependent chromatin remodeling complex SWI/SNF and is frequently mutated in human pancreatic ductal adenocarcinomas (PDACs). We investigated the… read more here.
Keywords: ptf1a cre; cre krasg12d; pdacs; pancreatic ductal ... See more keywords