Prolonged Pharmacokinetic and Pharmacodynamic Actions of a Pegylated Parathyroid Hormone (1‐34) Peptide Fragment
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DOI: 10.1002/jbmr.2917
Abstract: Polyethylene glycol (PEG) addition can prolong the pharmacokinetic and pharmacodynamic actions of a bioactive peptide in vivo, in part by impeding rates of glomerular filtration. For parathyroid hormone (PTH) peptides, pegylation could help in exploring… read more here.
Keywords: pth; pharmacodynamic actions; peptide; prolonged pharmacokinetic ... See more keywords
Hyperparathyroidism in Patients With X‐Linked Hypophosphatemia
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DOI: 10.1002/jbmr.3992
Abstract: X‐linked hypophosphatemia (XLH) is characterized by increased activity of circulating FGF23 resulting in renal phosphate wasting and abnormal bone mineralization. Hyperparathyroidism may develop in XLH patients; however, its prevalence, pathogenesis, and clinical presentation are not… read more here.
Keywords: pth; hypercalcemic hyperparathyroidism; pth concentrations; hyperparathyroidism ... See more keywords
Pleckstrin homology (PH) domain and Leucine Rich Repeat Phosphatase 1 (Phlpp1) Suppresses Parathyroid Hormone Receptor 1 (Pth1r) Expression and Signaling During Bone Growth
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4248
Abstract: Endochondral ossification is tightly controlled by a coordinated network of signaling cascades including parathyroid hormone (PTH). Pleckstrin homology (PH) domain and leucine rich repeat phosphatase 1 (Phlpp1) affects endochondral ossification by suppressing chondrocyte proliferation in… read more here.
Keywords: pth; phlpp1; pth1r expression; bone growth ... See more keywords
Efficacy and Safety of Parathyroid Hormone Replacement With TransCon PTH in Hypoparathyroidism: 26‐Week Results From the Phase 3 PaTHway Trial
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DOI: 10.1002/jbmr.4726
Abstract: Conventional therapy for hypoparathyroidism consisting of active vitamin D and calcium aims to alleviate hypocalcemia but fails to restore normal parathyroid hormone (PTH) physiology. PTH replacement therapy is the ideal physiologic treatment for hypoparathyroidism. The… read more here.
Keywords: transcon pth; hypoparathyroidism; therapy; week ... See more keywords
Conditional Loss of Nmp4 in Mesenchymal Stem Progenitor Cells Enhances PTH‐Induced Bone Formation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4732
Abstract: Activation of bone anabolic pathways is a fruitful approach for treating severe osteoporosis, yet FDA‐approved osteoanabolics, eg, parathyroid hormone (PTH), have limited efficacy. Improving their potency is a promising strategy for maximizing bone anabolic output.… read more here.
Keywords: nmp4 mesenchymal; pth induced; bone; mice ... See more keywords
Maintenance of increased bone mass after PTH withdrawal by sequential medicarpin treatment via augmentation of cAMP‐PKA pathway
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DOI: 10.1002/jcb.30313
Abstract: Osteoporosis is a metabolic bone disorder associated with impaired bone microarchitecture leading to fragility fractures. Long‐term usage of parathyroid hormone (PTH) enhances bone resorption and leads to osteosarcoma in rats which limits its exposure to… read more here.
Keywords: bone; pth withdrawal; medicarpin; treatment ... See more keywords
Fibroblast Growth Factor (FGF) 23 Regulates the Plasma Levels of Parathyroid Hormone In Vivo Through the FGF Receptor in Normocalcemia, But Not in Hypocalcemia
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DOI: 10.1007/s00223-017-0333-9
Abstract: The calcium and phosphate homeostasis is regulated by a complex interplay between parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and calcitriol. Experimental studies have demonstrated an inhibitory effect of FG23 on PTH production and… read more here.
Keywords: pth; fgf; secretion; hypocalcemia ... See more keywords
Postnatal deletion of β-catenin in osterix-expressing cells is necessary for bone growth and intermittent PTH-induced bone gain
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-017-0873-0
Abstract: Abstractwnt/β-catenin signaling has been shown to influence bone homeostasis and is important for parathyroid hormone (PTH)-induced bone gain. To further understand the role of β-catenin in the early stages of osteoblastic lineage cells for postnatal… read more here.
Keywords: pth; catenin mice; catenin; bone ... See more keywords
Production and applications of lead (II) oxide/poly(aniline-co-thiophene) composite materials for enhanced supercapacitor performance
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DOI: 10.1007/s10854-024-12706-1
Abstract: In this work, a novel approach was employed to prepare and utilize lead (II) oxide and poly(aniline-co-thiophene) (PANI-co-PTh) composite materials as electrode materials for supercapacitors, marking the first instance of such utilization in the literature.… read more here.
Keywords: pth; pani pth; oxide poly; poly aniline ... See more keywords
Prospects of Parathyroid Hormone in Therapeutic Intervention
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DOI: 10.1007/s10989-018-9744-3
Abstract: Biologically active peptides and proteins have wide applications as therapeutic agents as well as diagnostics. Parathyroid hormone (PTH), a polypeptide secreted by the parathyroid chief cells has been found to be an effective therapeutic protein… read more here.
Keywords: pth; prospects parathyroid; parathyroid hormone; therapeutic intervention ... See more keywords
Continuous PPI Treatment After Gastric Bypass Increases the Risk of Pathological PTH Levels at 10 Years Postoperatively
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DOI: 10.1007/s11695-025-07692-0
Abstract: Apart from massive weight loss, metabolic and bariatric surgery, especially gastric bypass (Roux-en-Y gastric bypass [RYGB]), can cause nutritional deficiencies. Proton pump inhibitors (PPI), relatively often used after RYGB, are associated with reduced calcium absorption.… read more here.
Keywords: pth levels; pth; gastric bypass; ppi treatment ... See more keywords