Prolonged Pharmacokinetic and Pharmacodynamic Actions of a Pegylated Parathyroid Hormone (1‐34) Peptide Fragment
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DOI: 10.1002/jbmr.2917
Abstract: Polyethylene glycol (PEG) addition can prolong the pharmacokinetic and pharmacodynamic actions of a bioactive peptide in vivo, in part by impeding rates of glomerular filtration. For parathyroid hormone (PTH) peptides, pegylation could help in exploring… read more here.
Keywords: pth; pharmacodynamic actions; peptide; prolonged pharmacokinetic ... See more keywords
Hyperparathyroidism in Patients With X‐Linked Hypophosphatemia
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DOI: 10.1002/jbmr.3992
Abstract: X‐linked hypophosphatemia (XLH) is characterized by increased activity of circulating FGF23 resulting in renal phosphate wasting and abnormal bone mineralization. Hyperparathyroidism may develop in XLH patients; however, its prevalence, pathogenesis, and clinical presentation are not… read more here.
Keywords: pth; hypercalcemic hyperparathyroidism; pth concentrations; hyperparathyroidism ... See more keywords
Pleckstrin homology (PH) domain and Leucine Rich Repeat Phosphatase 1 (Phlpp1) Suppresses Parathyroid Hormone Receptor 1 (Pth1r) Expression and Signaling During Bone Growth
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DOI: 10.1002/jbmr.4248
Abstract: Endochondral ossification is tightly controlled by a coordinated network of signaling cascades including parathyroid hormone (PTH). Pleckstrin homology (PH) domain and leucine rich repeat phosphatase 1 (Phlpp1) affects endochondral ossification by suppressing chondrocyte proliferation in… read more here.
Keywords: pth; phlpp1; pth1r expression; bone growth ... See more keywords
Efficacy and Safety of Parathyroid Hormone Replacement With TransCon PTH in Hypoparathyroidism: 26‐Week Results From the Phase 3 PaTHway Trial
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DOI: 10.1002/jbmr.4726
Abstract: Conventional therapy for hypoparathyroidism consisting of active vitamin D and calcium aims to alleviate hypocalcemia but fails to restore normal parathyroid hormone (PTH) physiology. PTH replacement therapy is the ideal physiologic treatment for hypoparathyroidism. The… read more here.
Keywords: transcon pth; hypoparathyroidism; therapy; week ... See more keywords
Conditional Loss of Nmp4 in Mesenchymal Stem Progenitor Cells Enhances PTH‐Induced Bone Formation
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DOI: 10.1002/jbmr.4732
Abstract: Activation of bone anabolic pathways is a fruitful approach for treating severe osteoporosis, yet FDA‐approved osteoanabolics, eg, parathyroid hormone (PTH), have limited efficacy. Improving their potency is a promising strategy for maximizing bone anabolic output.… read more here.
Keywords: nmp4 mesenchymal; pth induced; bone; mice ... See more keywords
Maintenance of increased bone mass after PTH withdrawal by sequential medicarpin treatment via augmentation of cAMP‐PKA pathway
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DOI: 10.1002/jcb.30313
Abstract: Osteoporosis is a metabolic bone disorder associated with impaired bone microarchitecture leading to fragility fractures. Long‐term usage of parathyroid hormone (PTH) enhances bone resorption and leads to osteosarcoma in rats which limits its exposure to… read more here.
Keywords: bone; pth withdrawal; medicarpin; treatment ... See more keywords
Fibroblast Growth Factor (FGF) 23 Regulates the Plasma Levels of Parathyroid Hormone In Vivo Through the FGF Receptor in Normocalcemia, But Not in Hypocalcemia
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DOI: 10.1007/s00223-017-0333-9
Abstract: The calcium and phosphate homeostasis is regulated by a complex interplay between parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and calcitriol. Experimental studies have demonstrated an inhibitory effect of FG23 on PTH production and… read more here.
Keywords: pth; fgf; secretion; hypocalcemia ... See more keywords
Postnatal deletion of β-catenin in osterix-expressing cells is necessary for bone growth and intermittent PTH-induced bone gain
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DOI: 10.1007/s00774-017-0873-0
Abstract: Abstractwnt/β-catenin signaling has been shown to influence bone homeostasis and is important for parathyroid hormone (PTH)-induced bone gain. To further understand the role of β-catenin in the early stages of osteoblastic lineage cells for postnatal… read more here.
Keywords: pth; catenin mice; catenin; bone ... See more keywords
Prospects of Parathyroid Hormone in Therapeutic Intervention
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DOI: 10.1007/s10989-018-9744-3
Abstract: Biologically active peptides and proteins have wide applications as therapeutic agents as well as diagnostics. Parathyroid hormone (PTH), a polypeptide secreted by the parathyroid chief cells has been found to be an effective therapeutic protein… read more here.
Keywords: pth; prospects parathyroid; parathyroid hormone; therapeutic intervention ... See more keywords
Parathyroid hormone in surgery-induced weight loss: no glucometabolic effects but potential adaptive response to skeletal loading
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DOI: 10.1007/s12020-017-1477-0
Abstract: PurposeIncreased parathyroid hormone (PTH) is commonly associated with obesity, and its role in the pathogenesis of obesity-related glucometabolic abnormalities is uncertain. We aimed to explore the relationships of PTH with glucose/insulin homeostasis parameters before and after… read more here.
Keywords: pth; surgery; parathyroid hormone; weight loss ... See more keywords
Mild progressive osseous heteroplasia overlap syndrome with PTH and TSH resistance appearing during adolescence and not early childhood
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DOI: 10.1007/s12020-021-02821-y
Abstract: Progressive osseous heteroplasia (POH), a genetic disorder, is associated with Albright’s hereditary osteodystrophy (AHO), pseudohypoparathyroidism, and primary osteoma cutis and has common features of superficial ossification and GNAS-inactivating mutations. Disorders due to GNAS-inactivating mutations are… read more here.
Keywords: pth; overlap syndrome; tsh resistance; early childhood ... See more keywords