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   Articles with "pth1r" as a keyword



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PTH1R translocation to primary cilia in mechanically‐stimulated ostecytes prevents osteoclast formation via regulation of CXCL5 and IL‐6 secretion

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recommendations! Published in 2022 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.30849

Abstract: Osteocytes respond to mechanical forces controlling osteoblast and osteoclast function. Mechanical stimulation decreases osteocyte apoptosis and promotes bone formation. Primary cilia have been described as potential mechanosensors in bone cells. Certain osteogenic responses induced by… read more here.

Keywords: pth1r; mechanically stimulated; cxcl5; mlo ... See more keywords
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A cumulative effect involving malfunction of the PTH1R and ATP4A genes explains a familial gastric neuroendocrine tumor with hypothyroidism and arthritis

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recommendations! Published in 2017 at "Gastric Cancer"

DOI: 10.1007/s10120-017-0723-8

Abstract: BackgroundType I gastric neuroendocrine tumors (gNETs) classically arise because of hypergastrinemia and involve destruction of parietal cells, which are responsible for gastric acid secretion through the ATP4A proton pump and for intrinsic factor production.MethodsBy whole… read more here.

Keywords: hypothyroidism; hormone; pth1r; rheumatoid arthritis ... See more keywords
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Translating in vitro ligand bias into in vivo efficacy.

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recommendations! Published in 2018 at "Cellular signalling"

DOI: 10.1016/j.cellsig.2017.05.002

Abstract: It is increasingly apparent that ligand structure influences both the efficiency with which G protein-coupled receptors (GPCRs) engage their downstream effectors and the manner in which they are activated. Thus, 'biased' agonists, synthetic ligands whose… read more here.

Keywords: pth1r; vitro ligand; arrestin pathway; efficacy ... See more keywords
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Molecular Mechanism of Ca2+ in the Allosteric Regulation of Human Parathyroid Hormone Receptor-1.

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recommendations! Published in 2021 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.1c00471

Abstract: Parathyroid hormone (PTH) is an endogenous ligand that activates the PTH type 1 receptor (PTH1R) signaling. Ca2+, a common second messenger, acts as an allosteric regulator for prolonging the activation of PTH1R. However, a clear… read more here.

Keywords: pth; allosteric regulation; mechanism; pth1r ... See more keywords
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PTH1R signalling regulates the mechanotransduction process of cementoblasts under cyclic tensile stress

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recommendations! Published in 2018 at "European Journal of Orthodontics"

DOI: 10.1093/ejo/cjx099

Abstract: Objective To investigate the regulatory role of type I parathyroid hormone receptor (PTH1R) signalling in the mechanotransduction process of cementoblasts under cyclic tensile stress (CTS). Materials and methods Immortalized cementoblast cell line OCCM-30 were employed… read more here.

Keywords: cyclic tensile; mechanotransduction process; pth1r signalling; pth1r ... See more keywords
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P0871THE IMPACT OF ENDOGENOUS PTH/PTH1R/ATF4 AXIS ON TRABECULAR AND CORTICAL BONE REMODELING AND BONE GROWTH OF YOUNG RATS WITH EXPERIMENTAL CHRONIC KIDNEY DISEASES

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recommendations! Published in 2020 at "Nephrology Dialysis Transplantation"

DOI: 10.1093/ndt/gfaa143.p0871

Abstract: Chronic kidney disease - mineral bone disorder (CKD–MBD) is one of the major clinical complications in patients with chronic kidney disease (CKD). Bone remodeling has been suggested to play a fundamental role in the maintenance… read more here.

Keywords: pth; pth1r; cortical bone; bone ... See more keywords
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Actions of Parathyroid Hormone Ligand Analogs in Humanized PTH1R Knock-In Mice.

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recommendations! Published in 2022 at "Endocrinology"

DOI: 10.1210/endocr/bqac054

Abstract: Rodent models are commonly used to evaluate parathyroid hormone (PTH) and PTH-related protein (PTHrP) ligands and analogs for their pharmacologic activities and potential therapeutic utility towards diseases of bone and mineral ion metabolism. Divergence, however,… read more here.

Keywords: hormone; pth1r; knock; parathyroid hormone ... See more keywords