Tctex-1 augments G protein-coupled receptor-mediated Gs signaling by activating adenylyl cyclase.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2020.11.011
Abstract: Proteins interacting with G protein-coupled receptors (GPCRs) can modulate signal transduction of these receptors. However, the regulatory mechanisms of the interacting proteins are diverse and largely unknown. We have previously shown that Tctex-1 (or DYNLT1)… read more here.
Keywords: adenylyl cyclase; tctex augments; protein coupled; pthr ... See more keywords
Phosphothreonine (pThr)-Based Multifunctional Peptide Catalysis for Asymmetric Baeyer-Villiger Oxidations of Cyclobutanones.
Sign Up to like & getrecommendations! Published in 2019 at "ACS catalysis"
DOI: 10.1021/acscatal.8b04132
Abstract: Biologically inspired phosphothreonine (pThr)-embedded peptides that function as chiral Brønsted acid catalysts for enantioselective Baeyer-Villiger oxidations (BV) of cyclobutanones with aqueous H2O2 are reported herein. Complementary to traditional BINOL-derived chiral phosphoric acids (CPAs), the functional… read more here.
Keywords: baeyer villiger; pthr based; oxidations cyclobutanones; phosphothreonine pthr ... See more keywords
Scribble scrambles parathyroid hormone receptor interactions to regulate phosphate and vitamin D homeostasis.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2220851120
Abstract: G protein-coupled receptors, including PTHR, are pivotal for controlling metabolic processes ranging from serum phosphate and vitamin D levels to glucose uptake, and cytoplasmic interactors may modulate their signaling, trafficking, and function. We now show… read more here.
Keywords: vitamin levels; vitamin; scrambles parathyroid; pthr ... See more keywords
Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation
Sign Up to like & getrecommendations! Published in 2021 at "Science Signaling"
DOI: 10.1126/scisignal.abc5944
Abstract: Description Physiological responses to parathyroid hormone depend on the subcellular location of receptor activity. Location matters for GPCR signaling Parathyroid hormone (PTH) receptor (PTHR) is a G protein–coupled receptor (GPCR) that controls vitamin D, Ca2+,… read more here.
Keywords: pth; location; camp production; pthr ... See more keywords