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   Articles with "pthrp" as a keyword



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Role of PTHrP nuclear localization and carboxyl terminus sequences in postnatal spinal cord development

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recommendations! Published in 2020 at "Developmental Neurobiology"

DOI: 10.1002/dneu.22798

Abstract: Parathyroid hormone‐related peptide (PTHrP) acts under physiological conditions to regulate normal development of several tissues and organs. The role of PTHrP in spinal cord development has not been characterized. Pthrp knock in (Pthrp KI) mice… read more here.

Keywords: pthrp; cord development; role; development ... See more keywords

PTHrP promotes development of mouse preimplantation embryos through the AKT/cyclin D1 pathway and nuclear translocation of HDAC4

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recommendations! Published in 2021 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.30362

Abstract: Parathyroid hormone‐related protein (PTHrP), the main cause of humoral hypercalcemia in malignancies, promotes cell proliferation and delays terminal cell maturation during embryonic development. Our previous study reported that PTHrP plays important roles in blastocyst formation,… read more here.

Keywords: pthrp; hdac4; embryonic development; preimplantation ... See more keywords

Involvement of the Parathyroid Hormone-Related Protein on Changes in the CYP3A Expression in Cancer Cachexia.

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recommendations! Published in 2021 at "Molecular pharmaceutics"

DOI: 10.1021/acs.molpharmaceut.1c00490

Abstract: Parathyroid hormone-related protein (PTHrP), which is secreted from a tumor, contributes to the progression of cachexia, a condition that is observed in half of all cancer patients. Although drug clearance was reported to decrease in… read more here.

Keywords: protein; pthrp; expression; cancer cachexia ... See more keywords

Deletion of PTHrP nuclear localization sequence and carboxyl terminus leads to lung dysplasia

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-08163-3

Abstract: Parathyroid hormone-related peptide (PTHrP) is a factor that plays an important role in the growth and development of multiple organs. The role of PTHrP in lung development has not been characterized. In order to further… read more here.

Keywords: lung; pthrp; sequence; pthrp nuclear ... See more keywords

Abstract PR09: Pancreatic cancer cachexia is mediated by tumor-derived PTHrP

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recommendations! Published in 2024 at "Cancer Research"

DOI: 10.1158/1538-7445.panca2023-pr09

Abstract: Purpose: Our prior work has established that metastasis is initiated by PTHrP-driven mechanisms in PDAC. PTHLH (the gene encoding the PTHrP protein) is directly adjacent to and co-amplified along with KRAS, and this amplicon is… read more here.

Keywords: mice; pthrp; tumor; pancreatic cancer ... See more keywords

Abstract PR007: Pancreatic cancer cachexia is mediated by tumor-derived PTHrP

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recommendations! Published in 2024 at "Cancer Research"

DOI: 10.1158/1538-7445.tumbody-pr007

Abstract: Purpose: Our prior work has established that metastasis is initiated by PTHrP-driven mechanisms in pancreatic ductal adenocarcinoma (PDAC). PTHLH (the gene encoding the PTHrP protein) is directly adjacent to and co-amplified along with KRAS, the… read more here.

Keywords: cancer; pthrp; tumor; pancreatic cancer ... See more keywords

HIF-2-dependent Regulation of PTHrP and Paraneoplastic Hypercalcemia in Aggressive Clear Cell Renal Cell Carcinoma.

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recommendations! Published in 2025 at "Cancer discovery"

DOI: 10.1158/2159-8290.cd-25-0638

Abstract: Renal cell carcinoma (RCC) patients with hypercalcemia (HC) have worse outcomes. HC often involves PTHrP, and the role of HIF-2 is incompletely understood. Leveraging RCC tumorgraft (TG) models of HC, which were characterized by tumor… read more here.

Keywords: pthrp; cell; cell carcinoma; hif ... See more keywords

PTHrP May Contribute to Cachexia Accompanying Multiple Myeloma Bone Disease

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recommendations! Published in 2018 at "Blood"

DOI: 10.1182/blood-2018-99-115680

Abstract: Background: Cachexia, an energy-wasting disorder of adipose and skeletal muscles, occurs commonly in advanced cancers and is a serious problem that interferes with response to treatment and affects quality of life. Treatment or cachexia is… read more here.

Keywords: pthrp; cachexia; myeloma; bone ... See more keywords

Effect of parathyroid hormone-related protein on odontogenic differentiation in human dental pulp cells

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recommendations! Published in 2020 at "BMC Oral Health"

DOI: 10.1186/s12903-020-01085-8

Abstract: Background Parathyroid hormone-related protein (PTHrP) plays an important role in many physiological processes, including bone regeneration. The function of PTHrP is similar to PTH. It promotes osteogenic differentiation in MC3T3-E1 cells. The aim of this… read more here.

Keywords: pthrp; parathyroid hormone; odontogenic differentiation; differentiation ... See more keywords

7759 Undetectable PTHrP and Elevated Il-6 in a 517759 Year Old Male With Clear Cell Renal Carcinoma, Complicated by Paraneoplastic Hypercalcemia

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recommendations! Published in 2024 at "Journal of the Endocrine Society"

DOI: 10.1210/jendso/bvae163.1074

Abstract: Abstract Disclosure: E. Cedeno: None. T. Patel: None. C. Zacharia: None. Title Undetectable PTHrP and elevated IL-6 in a 51-year-old male with clear cell renal carcinoma, complicated by paraneoplastic hypercalcemia. Introduction: Malignant hypercalcemia as a… read more here.

Keywords: rcc; pthrp elevated; pthrp; case ... See more keywords

8270 A Rare Case Of PTHrP Induced Severe Hypercalcemia Secondary To Squamous Cell Carcinoma Of Tongue

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recommendations! Published in 2024 at "Journal of the Endocrine Society"

DOI: 10.1210/jendso/bvae163.345

Abstract: Abstract Disclosure: N. Vennelaganti: None. S. Vennelaganti: None. K. McCowen: None. Background: PTHrP-mediated hypercalcemia is often associated with solid organ malignancies and indicates a poor prognosis. The occurrence of this condition due to SCC of… read more here.

Keywords: oncology; severe hypercalcemia; tongue; pthrp ... See more keywords