Role of PTHrP nuclear localization and carboxyl terminus sequences in postnatal spinal cord development
Sign Up to like & getrecommendations! Published in 2020 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22798
Abstract: Parathyroid hormone‐related peptide (PTHrP) acts under physiological conditions to regulate normal development of several tissues and organs. The role of PTHrP in spinal cord development has not been characterized. Pthrp knock in (Pthrp KI) mice… read more here.
Keywords: pthrp; cord development; role; development ... See more keywords
PTHrP promotes development of mouse preimplantation embryos through the AKT/cyclin D1 pathway and nuclear translocation of HDAC4
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30362
Abstract: Parathyroid hormone‐related protein (PTHrP), the main cause of humoral hypercalcemia in malignancies, promotes cell proliferation and delays terminal cell maturation during embryonic development. Our previous study reported that PTHrP plays important roles in blastocyst formation,… read more here.
Keywords: pthrp; hdac4; embryonic development; preimplantation ... See more keywords
Involvement of the Parathyroid Hormone-Related Protein on Changes in the CYP3A Expression in Cancer Cachexia.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00490
Abstract: Parathyroid hormone-related protein (PTHrP), which is secreted from a tumor, contributes to the progression of cachexia, a condition that is observed in half of all cancer patients. Although drug clearance was reported to decrease in… read more here.
Keywords: protein; pthrp; expression; cancer cachexia ... See more keywords
PTHrP May Contribute to Cachexia Accompanying Multiple Myeloma Bone Disease
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-115680
Abstract: Background: Cachexia, an energy-wasting disorder of adipose and skeletal muscles, occurs commonly in advanced cancers and is a serious problem that interferes with response to treatment and affects quality of life. Treatment or cachexia is… read more here.
Keywords: pthrp; cachexia; myeloma; bone ... See more keywords
Effect of parathyroid hormone-related protein on odontogenic differentiation in human dental pulp cells
Sign Up to like & getrecommendations! Published in 2020 at "BMC Oral Health"
DOI: 10.1186/s12903-020-01085-8
Abstract: Background Parathyroid hormone-related protein (PTHrP) plays an important role in many physiological processes, including bone regeneration. The function of PTHrP is similar to PTH. It promotes osteogenic differentiation in MC3T3-E1 cells. The aim of this… read more here.
Keywords: pthrp; parathyroid hormone; odontogenic differentiation; differentiation ... See more keywords
From Good to Bad: The Opposing Effects of PTHrP on Tumor Growth, Dormancy, and Metastasis Throughout Cancer Progression
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.644303
Abstract: Parathyroid hormone related protein (PTHrP) is a multifaceted protein with several biologically active domains that regulate its many roles in normal physiology and human disease. PTHrP causes humoral hypercalcemia of malignancy (HHM) through its endocrine… read more here.
Keywords: pthrp; dormancy; metastasis; cancer progression ... See more keywords
PTHrP Modulates the Proliferation and Osteogenic Differentiation of Craniofacial Fibrous Dysplasia-Derived BMSCs
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087616
Abstract: Fibrous dysplasia (FD) is a skeletal stem cell disease caused by mutations in the guanine nucleotide-binding protein, alpha-stimulating activity polypeptide (GNAS) gene, which results in the abnormal accumulation of cyclic adenosine monophosphate (cAMP) and hyperactivation… read more here.
Keywords: pthrp; fibrous dysplasia; derived bmscs; osteogenic differentiation ... See more keywords
Involvement of parathyroid hormone-related peptide in the aggressive phenotype of colorectal cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v27.i41.7025
Abstract: Colorectal cancer (CRC) remains one of the leading causes of mortality from malignant diseases worldwide. In general terms, CRC presents high heterogeneity due to the influence of different genetic and environmental factors; also, the neoplastic… read more here.
Keywords: pthrp; parathyroid hormone; crc cells; crc ... See more keywords