LAUSR

PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis

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1 Published in 2017 at "Neurobiology of Aging"

DOI: 10.1016/j.neurobiolaging.2017.03.016

Abstract: We show that amyloid-β1-42 (Aβ42) triggers a conformational change in the scaffolding protein filamin A (FLNA) to induce FLNA associations with α7-nicotinic acetylcholine receptor (α7nAChR) and toll-like receptor 4 (TLR4). These aberrant associations respectively enable… read more here.

Keywords: alzheimer disease; pti 125; filamin; conformation ... See more keywords