Determination of protein tyrosine kinase-7 concentration using electrocatalytic reaction and an aptamer-antibody sandwich assay platform
Sign Up to like & getrecommendations! Published in 2021 at "Catalysis Today"
DOI: 10.1016/j.cattod.2019.05.029
Abstract: Abstract An aptamer-antibody sandwich assay for the voltammetric determination of protein tyrosine kinase-7 (PTK7) concentrations in buffer and human serum solutions was developed. A DNA aptamer specific to PTK7 was covalently immobilized onto gold nanoparticles… read more here.
Keywords: aptamer antibody; ptk7; antibody; concentration ... See more keywords
Proteomic and Phosphoproteomic Analyses Reveal the Oncogenic Role of PTK7-NDRG1 Axis in Non-small-cell Lung Cancer Cell Resistance to AZD9291.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00479
Abstract: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are the most important chemotherapeutics for non-small-cell lung cancer (NSCLC) therapy. The resistance to EGFR-TKIs is one of the biggest obstacles to NSCLC outcome. In this study,… read more here.
Keywords: cell; non small; small cell; resistance ... See more keywords
Abstract LB216: Discovery of BCG033, a novel anti-PTK7 x TROP2 bispecific antibody-drug conjugate with promising efficacy against triple-negative breast cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb216
Abstract: Triple-negative breast cancer (TNBC) accounts for 15-20% of metastatic breast cancer incidence, and remains an area of unmet clinical need due to the low rates of overall survival. Recently, the TROP2-targeting ADC sacituzumab govitecan has… read more here.
Keywords: ptk7 trop2; breast cancer; tnbc; ptk7 ... See more keywords
PTK7 is a novel oncogenic target for esophageal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "World Journal of Surgical Oncology"
DOI: 10.1186/s12957-017-1172-x
Abstract: BackgroundOverexpression of PTK7 has been found in multiple cancers and has been proposed to serve as a prognostic marker for intrahepatic cholangiocarcinoma. Its role in esophageal cancer, however, remains to be clarified. We hypothesize that… read more here.
Keywords: esophageal squamous; cell carcinoma; squamous cell; ptk7 ... See more keywords
PF-06647020 (PF-7020), an antibody-drug conjugate (ADC) targeting protein tyrosine kinase 7 (PTK7), in patients (pts) with advanced solid tumors: Results of a phase I dose escalation and expansion study.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.5565
Abstract: 5565Background: PF-7020 is an ADC comprising of a humanized monoclonal antibody against PTK7, a cleavable valine-citrulline linker and auristatin payload that is being investigated in an ongoing Ph... read more here.
Keywords: adc; 7020 antibody; antibody; 06647020 7020 ... See more keywords
PTK7 Faces the Wnt in Development and Disease
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2017.00031
Abstract: PTK7 (protein tyrosine kinase 7) is an evolutionarily conserved transmembrane receptor regulating various processes in embryonic development and tissue homeostasis. On a cellular level PTK7 affects the establishment of cell polarity, the regulation of cell… read more here.
Keywords: wnt signaling; development disease; ptk7 faces; ptk7 ... See more keywords
PTK7-Targeting CAR T-Cells for the Treatment of Lung Cancer and Other Malignancies
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.665970
Abstract: In spite of impressive success in treating hematologic malignancies, adoptive therapy with chimeric antigen receptor modified T cells (CAR T) has not yet been effective in solid tumors, where identification of suitable tumor-specific antigens remains… read more here.
Keywords: ptk7; lung cancer; cancer; car ... See more keywords
PTK7, a Catalytically Inactive Receptor Tyrosine Kinase, Increases Oncogenic Phenotypes in Xenograft Tumors of Esophageal Squamous Cell Carcinoma KYSE-30 Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23042391
Abstract: Protein tyrosine kinase 7 (PTK7), a catalytically defective receptor protein tyrosine kinase, is upregulated in tumor tissues and cell lines of esophageal squamous cell carcinoma (ESCC). We showed that PTK7 plays an oncogenic role in… read more here.
Keywords: cell; xenograft tumors; tyrosine kinase; kyse cells ... See more keywords
Anti-PTK7 Monoclonal Antibodies Exhibit Anti-Tumor Activity at the Cellular Level and in Mouse Xenograft Models of Esophageal Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012195
Abstract: PTK7 is a catalytically defective receptor protein tyrosine kinase upregulated in various cancers, including esophageal squamous cell carcinoma (ESCC). In previous studies, we observed a positive correlation between PTK7 expression levels and tumorigenicity in various… read more here.
Keywords: mouse xenograft; cell; ptk7 mabs; esophageal squamous ... See more keywords