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   Articles with "ptm" as a keyword



Mapping of barley susceptibility/resistance QTL against spot form net blotch caused by Pyrenophora teres f. maculata using RIL populations

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recommendations! Published in 2019 at "Theoretical and Applied Genetics"

DOI: 10.1007/s00122-019-03328-x

Abstract: Spot form net blotch (SFNB) caused by the necrotrophic fungal pathogen Pyrenophora teres f. maculata (Ptm) is an important disease of barley worldwide including the major barley production regions of North America. To characterize SFNB… read more here.

Keywords: ril populations; susceptibility; barley; resistance ... See more keywords

Nanotechnological approaches for pentamidine delivery

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recommendations! Published in 2022 at "Drug Delivery and Translational Research"

DOI: 10.1007/s13346-022-01127-4

Abstract: Pentamidine (PTM), which is a diamine that is widely known for its antimicrobial activity, is a very interesting drug whose mechanism of action is not fully understood. In recent years, PTM has been proposed as… read more here.

Keywords: approaches pentamidine; drug; delivery; ptm ... See more keywords

Olfactory responses of adult Potato Tuber Moth, Phthorimaea operculella (Zeller) measured by attraction relative to the tomato leaf volatiles

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recommendations! Published in 2019 at "Journal of Asia-Pacific Entomology"

DOI: 10.1016/j.aspen.2019.04.007

Abstract: Abstract The potato tuber moth (PTM) is an oligophagous herbivore and a severe pest of solanaceous crops in many countries of the world. Previously, we reported host expansion and damage potential of PTM on tomato,… read more here.

Keywords: tomato leaf; potato tuber; ptm; tomato ... See more keywords

Enrichment of oxidised peptides of oxidised allows identification of oxidized cysteine residues in signaling proteins in vivo

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recommendations! Published in 2018 at "Free Radical Biology and Medicine"

DOI: 10.1016/j.freeradbiomed.2018.10.118

Abstract: Detection of oxidative post-translational modifications (ox-PTMs) of Cys residues in mammalian signaling proteins in vivo is one of the current challenges in redox biology. Ox-PTM residues labeling using maleimide switch methods coupled to mass spectrometry… read more here.

Keywords: cys; proteins vivo; biology; signaling proteins ... See more keywords

Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family.

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recommendations! Published in 2021 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.1c01076

Abstract: Post-translational modification (PTM) on protein plays important roles in the regulation of cellular function and disease pathogenesis. The systematic analysis of PTM dynamics presents great opportunities to enlarge the target space by PTM allosteric regulation.… read more here.

Keywords: post translational; translational modification; drug design; kinase family ... See more keywords

FAIMS Enhances the Detection of PTM Crosstalk Sites

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recommendations! Published in 2022 at "Journal of Proteome Research"

DOI: 10.1021/acs.jproteome.1c00721

Abstract: Protein post-translational modifications (PTMs) enable cells to rapidly change in response to biological stimuli. With hundreds of different PTMs, understanding these control mechanisms is complex. To date, efforts have focused on investigating the effect of… read more here.

Keywords: crosstalk sites; detection ptm; ptm crosstalk; crosstalk ... See more keywords

Cryptic and Stereospecific Hydroxylation, Oxidation, and Reduction in Platensimycin and Platencin Biosynthesis.

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recommendations! Published in 2019 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.8b13452

Abstract: Platensimycin (PTM) and platencin (PTN) are highly functionalized bacterial diterpenoids of ent-kauranol and ent-atiserene biosynthetic origin. C7 oxidation in the B-ring plays a key biosynthetic role in generating structural complexity known for ent-kaurane and ent-atisane… read more here.

Keywords: platencin; biosynthesis; oxidation; hydroxyl ... See more keywords

PTM-Mamba: a PTM-aware protein language model with bidirectional gated Mamba blocks

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recommendations! Published in 2025 at "Nature Methods"

DOI: 10.1038/s41592-025-02656-9

Abstract: Current protein language models (LMs) accurately encode protein properties but have yet to represent post-translational modifications (PTMs), which are crucial for proteomic diversity and influence protein structure, function and interactions. To address this gap, we… read more here.

Keywords: language; aware protein; ptm; ptm mamba ... See more keywords

DeepMVP: deep learning models trained on high-quality data accurately predict PTM sites and variant-induced alterations

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recommendations! Published in 2025 at "Nature Methods"

DOI: 10.1038/s41592-025-02797-x

Abstract: Post-translational modifications (PTMs) are critical regulators of protein function, and their disruption is a key mechanism by which missense variants contribute to disease. Accurate PTM site prediction using deep learning can help identify PTM-altering variants,… read more here.

Keywords: deep learning; high quality; ptm; deepmvp deep ... See more keywords

A comparative metabologenomic approach reveals mechanistic insights into Streptomyces antibiotic crypticity

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recommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2103515118

Abstract: Significance Streptomyces genomes harbor a trove of biosynthetic gene clusters (BGCs) that encode for drug-like molecules. However, only a fraction of these readily yield expected products. To investigate why this is, we used polycyclic tetramate… read more here.

Keywords: production; ptm producers; antibiotic crypticity; approach ... See more keywords

PTMint database of experimentally verified PTM regulation on protein–protein interaction

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recommendations! Published in 2022 at "Bioinformatics"

DOI: 10.1093/bioinformatics/btac823

Abstract: Abstract Motivation Post-translational modification (PTM) is an important biochemical process. which includes six most well-studied types: phosphorylation, acetylation, methylation, sumoylation, ubiquitylation and glycosylation. PTM is involved in various cell signaling pathways and biological processes. Abnormal… read more here.

Keywords: protein protein; database; ptmint; regulation ... See more keywords