Effects of rifampicin on antineoplastic drug pyrotinib maleate pharmacokinetics in healthy subjects
Sign Up to like & getrecommendations! Published in 2022 at "Investigational New Drugs"
DOI: 10.1007/s10637-022-01241-7
Abstract: Pyrotinib (PTN), an irreversible EGFR/HER2 dual tyrosine kinase inhibitor used for treating HER2-positive breast cancer, is primarily metabolized by cytochrome P450 (CYP)3A4 isozyme. Rifampicin (RIF) is a strong index CYP3A4 inducer. Therefore, the study aimed… read more here.
Keywords: pyrotinib; study; rif; rifampicin antineoplastic ... See more keywords
QTL identification and KASP marker development for productive tiller and fertile spikelet numbers in two high-yielding hard white spring wheat cultivars
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Breeding"
DOI: 10.1007/s11032-018-0894-y
Abstract: Selecting high-yielding wheat cultivars with more productive tillers per unit area (PTN) combined with more fertile spikelets per spike (fSNS) is difficult. QTL mapping of these traits may aid understanding of this bottleneck and accelerate… read more here.
Keywords: qfsns uia; wheat; qtl; ptn ... See more keywords
A quantitatively controllable mesoscopic reliability model of an interdependent public transit network considering congestion, time-delay interaction and self-organization effects
Sign Up to like & getrecommendations! Published in 2019 at "Nonlinear Dynamics"
DOI: 10.1007/s11071-019-04831-y
Abstract: This paper establishes a multi-parameter controlling cascading failures (CFs) model for measuring interdependent public transit network (PTN) reliability under mesoscopic perspective. First, we abstract the weighted PTN and geospatial PTN into a double-layered passenger flow… read more here.
Keywords: public transit; time delay; interaction; model ... See more keywords
Landmark Technique vs Ultrasound-Guided Approach for Posterior Tibial Nerve Block in Cadaver Models.
Sign Up to like & getrecommendations! Published in 2020 at "Indian journal of orthopaedics"
DOI: 10.1007/s43465-019-00012-6
Abstract: Background The use of ultrasound for peripheral nerve blocks has proven extremely useful for improving the accuracy and efficacy of many regional anesthetic techniques. There remain a few nerve blocks which have lagged behind in… read more here.
Keywords: technique; block; ptn; ultrasound guided ... See more keywords
Apically Extruded Debris after Retreatment Procedure with Reciproc, ProTaper Next, and Twisted File Adaptive Instruments
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Endodontics"
DOI: 10.1016/j.joen.2016.12.003
Abstract: Introduction The aim of this study was to compare the amount of debris extruded from the apex during retreatment procedures with ProTaper Next (PTN; Dentsply Maillefer, Ballaigues, Switzerland), Reciproc (RCP; VDW, Munich, Germany), and Twisted… read more here.
Keywords: twisted file; ptn; amount debris; debris extruded ... See more keywords
Electrocatalytic Hydrogen Evolution at Full Atomic Utilization over ITO-Supported Sub-nano-Ptn Clusters: High, Size-Dependent Activity Controlled by Fluxional Pt Hydride Species.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c13063
Abstract: A combination of density functional theory (DFT) and experiments with atomically size-selected Ptn clusters deposited on indium-tin oxide (ITO) electrodes was used to examine the effects of applied potential and Ptn size on the electrocatalytic… read more here.
Keywords: ptn; ptn clusters; activity; ito ... See more keywords
Role of RPTPβ/ζ in neuroinflammation and microglia-neuron communication
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-76415-5
Abstract: Pleiotrophin (PTN) is a cytokine that is upregulated in different neuroinflammatory disorders. Using mice with transgenic PTN overexpression in the brain (Ptn-Tg), we have found a positive correlation between iNos and Tnfα mRNA and Ptn… read more here.
Keywords: ptn; neuron communication; role; rptp ... See more keywords
The link between menin and pleiotrophin in the tumor biology of pancreatic neuroendocrine neoplasms.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer science"
DOI: 10.1111/cas.15301
Abstract: MEN1, which encodes menin protein, is the most frequently mutated gene in pancreatic neuroendocrine neoplasms (pNEN). Pleiotrophin (PTN) was reported being a downstream factor of menin and to promote metastasis in different tumor entities. In… read more here.
Keywords: ptn; menin; pancreatic neuroendocrine; metastasis ... See more keywords
Pleiotrophin, a target of miR‐384, promotes proliferation, metastasis and lipogenesis in HBV‐related hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13213
Abstract: Hepatitis B virus (HBV) infection plays a crucial role and is a major cause of hepatocellular carcinoma (HCC) in China. microRNAs (miRNAs) have emerged as key players in hepatic steatosis and carcinogenesis. We found that… read more here.
Keywords: hcc; proliferation metastasis; hbv related; ptn ... See more keywords
Natural history of trigeminal neuralgia - A hospital-based retrospective study.
Sign Up to like & getrecommendations! Published in 2019 at "Oral diseases"
DOI: 10.1111/odi.13263
Abstract: OBJECTIVE The objective of this study was to assess the natural history of trigeminal neuralgia (TN) and pre-trigeminal neuralgia (PTN) in a hospital-based sample using a retrospective and descriptive study design. METHODS This study followed… read more here.
Keywords: ptn; study; natural history; trigeminal neuralgia ... See more keywords
Biosynthesis of 2′-Chloropentostatin and 2′-Amino-2′-Deoxyadenosine Highlights a Single Gene Cluster Responsible for Two Independent Pathways in Actinomadura sp. Strain ATCC 39365
Sign Up to like & getrecommendations! Published in 2017 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.00078-17
Abstract: ABSTRACT 2′-Chloropentostatin (2′-Cl PTN, 2′-chloro-2′-deoxycoformycin) and 2′-amino-2′-deoxyadenosine (2′-amino dA) are two adenosine-derived nucleoside antibiotics coproduced by Actinomadura sp. strain ATCC 39365. 2′-Cl PTN is a potent adenosine deaminase (ADA) inhibitor featuring an intriguing 1,3-diazepine ring,… read more here.
Keywords: biosynthesis; amino; ptn; strain atcc ... See more keywords