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   Articles with "ptn" as a keyword



Effects of rifampicin on antineoplastic drug pyrotinib maleate pharmacokinetics in healthy subjects

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recommendations! Published in 2022 at "Investigational New Drugs"

DOI: 10.1007/s10637-022-01241-7

Abstract: Pyrotinib (PTN), an irreversible EGFR/HER2 dual tyrosine kinase inhibitor used for treating HER2-positive breast cancer, is primarily metabolized by cytochrome P450 (CYP)3A4 isozyme. Rifampicin (RIF) is a strong index CYP3A4 inducer. Therefore, the study aimed… read more here.

Keywords: pyrotinib; study; rif; rifampicin antineoplastic ... See more keywords

QTL identification and KASP marker development for productive tiller and fertile spikelet numbers in two high-yielding hard white spring wheat cultivars

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recommendations! Published in 2018 at "Molecular Breeding"

DOI: 10.1007/s11032-018-0894-y

Abstract: Selecting high-yielding wheat cultivars with more productive tillers per unit area (PTN) combined with more fertile spikelets per spike (fSNS) is difficult. QTL mapping of these traits may aid understanding of this bottleneck and accelerate… read more here.

Keywords: qfsns uia; wheat; qtl; ptn ... See more keywords

A quantitatively controllable mesoscopic reliability model of an interdependent public transit network considering congestion, time-delay interaction and self-organization effects

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recommendations! Published in 2019 at "Nonlinear Dynamics"

DOI: 10.1007/s11071-019-04831-y

Abstract: This paper establishes a multi-parameter controlling cascading failures (CFs) model for measuring interdependent public transit network (PTN) reliability under mesoscopic perspective. First, we abstract the weighted PTN and geospatial PTN into a double-layered passenger flow… read more here.

Keywords: public transit; time delay; interaction; model ... See more keywords
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Landmark Technique vs Ultrasound-Guided Approach for Posterior Tibial Nerve Block in Cadaver Models.

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recommendations! Published in 2020 at "Indian journal of orthopaedics"

DOI: 10.1007/s43465-019-00012-6

Abstract: Background The use of ultrasound for peripheral nerve blocks has proven extremely useful for improving the accuracy and efficacy of many regional anesthetic techniques. There remain a few nerve blocks which have lagged behind in… read more here.

Keywords: technique; block; ptn; ultrasound guided ... See more keywords

Apically Extruded Debris after Retreatment Procedure with Reciproc, ProTaper Next, and Twisted File Adaptive Instruments

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recommendations! Published in 2017 at "Journal of Endodontics"

DOI: 10.1016/j.joen.2016.12.003

Abstract: Introduction The aim of this study was to compare the amount of debris extruded from the apex during retreatment procedures with ProTaper Next (PTN; Dentsply Maillefer, Ballaigues, Switzerland), Reciproc (RCP; VDW, Munich, Germany), and Twisted… read more here.

Keywords: twisted file; ptn; amount debris; debris extruded ... See more keywords

Electrocatalytic Hydrogen Evolution at Full Atomic Utilization over ITO-Supported Sub-nano-Ptn Clusters: High, Size-Dependent Activity Controlled by Fluxional Pt Hydride Species.

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recommendations! Published in 2023 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.2c13063

Abstract: A combination of density functional theory (DFT) and experiments with atomically size-selected Ptn clusters deposited on indium-tin oxide (ITO) electrodes was used to examine the effects of applied potential and Ptn size on the electrocatalytic… read more here.

Keywords: ptn; ptn clusters; activity; ito ... See more keywords

Astrocytic pleiotrophin deficiency in the prefrontal cortex contributes to stress-induced depressive-like responses in male mice

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-57924-1

Abstract: Astrocytes are closely linked to depression, and the prefrontal cortex (PFC) is an important brain region involved in major depressive disorder (MDD). However, the underlying mechanism by which astrocytes within PFC contribute to MDD remains… read more here.

Keywords: male mice; depression; prefrontal cortex; ptn ... See more keywords

Role of RPTPβ/ζ in neuroinflammation and microglia-neuron communication

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-76415-5

Abstract: Pleiotrophin (PTN) is a cytokine that is upregulated in different neuroinflammatory disorders. Using mice with transgenic PTN overexpression in the brain (Ptn-Tg), we have found a positive correlation between iNos and Tnfα mRNA and Ptn… read more here.

Keywords: ptn; neuron communication; role; rptp ... See more keywords

The roles of pleiotrophin in brain injuries: a narrative review of the literature

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recommendations! Published in 2025 at "Annals of Medicine"

DOI: 10.1080/07853890.2025.2452353

Abstract: Abstract Background Pleiotrophin (PTN), a secreted multifunctional growth factor, is highly expressed in the developing brain. Recently, many studies have indicated that PTN participates in the development of brain and plays a neuroprotection after brain… read more here.

Keywords: brain; review; brain injury; brain injuries ... See more keywords

The link between menin and pleiotrophin in the tumor biology of pancreatic neuroendocrine neoplasms.

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recommendations! Published in 2022 at "Cancer science"

DOI: 10.1111/cas.15301

Abstract: MEN1, which encodes menin protein, is the most frequently mutated gene in pancreatic neuroendocrine neoplasms (pNEN). Pleiotrophin (PTN) was reported being a downstream factor of menin and to promote metastasis in different tumor entities. In… read more here.

Keywords: ptn; menin; pancreatic neuroendocrine; metastasis ... See more keywords

Pleiotrophin, a target of miR‐384, promotes proliferation, metastasis and lipogenesis in HBV‐related hepatocellular carcinoma

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recommendations! Published in 2017 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.13213

Abstract: Hepatitis B virus (HBV) infection plays a crucial role and is a major cause of hepatocellular carcinoma (HCC) in China. microRNAs (miRNAs) have emerged as key players in hepatic steatosis and carcinogenesis. We found that… read more here.

Keywords: hcc; proliferation metastasis; hbv related; ptn ... See more keywords