Activating EGFR Signaling Attenuates Osteoarthritis Development Following Loading Injury in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4717
Abstract: Posttraumatic osteoarthritis (PTOA) results in joint pain, loss of joint function, and impaired quality of daily life in patients with limited treatment options. We previously demonstrated that epidermal growth factor receptor (EGFR) signaling is essential… read more here.
Keywords: ptoa; development; cartilage; injury ... See more keywords
Understanding Early-Stage Posttraumatic Osteoarthritis for Future Prospects of Diagnosis: from Knee to Temporomandibular Joint
Sign Up to like & getrecommendations! Published in 2021 at "Current Osteoporosis Reports"
DOI: 10.1007/s11914-021-00661-3
Abstract: Many mechanical load-bearing joints of the body are prone to posttraumatic osteoarthritis (PTOA), including the knee joint and temporomandibular joint (TMJ). Early detection of PTOA can be beneficial in prevention or alleviating further progression of… read more here.
Keywords: early stage; temporomandibular joint; posttraumatic osteoarthritis; ptoa ... See more keywords
A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-77735-2
Abstract: Post-traumatic osteoarthritis (PTOA) is a major cause which hinders patients from the recovery after intra-articular injuries or surgeries. Currently, no effective treatment is available. In this study, we showed that inhibition of the acute stage… read more here.
Keywords: post traumatic; therapeutic agent; traumatic osteoarthritis; ptoa ... See more keywords
Characterization of Non-Invasively Induced Post-Traumatic Osteoarthritis in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11091783
Abstract: The pathophysiology of post-traumatic arthritis (PTOA) is not fully understood. This study used non-invasive repetitive mechanical loading (ML) mouse models to study biochemical, biomechanical, and pain-related behavioral changes induced in mice. Mouse models reflected the… read more here.
Keywords: ptoa; mouse; characterization non; mice ... See more keywords