Activating EGFR Signaling Attenuates Osteoarthritis Development Following Loading Injury in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4717
Abstract: Posttraumatic osteoarthritis (PTOA) results in joint pain, loss of joint function, and impaired quality of daily life in patients with limited treatment options. We previously demonstrated that epidermal growth factor receptor (EGFR) signaling is essential… read more here.
Keywords: ptoa; development; cartilage; injury ... See more keywords
Understanding Early-Stage Posttraumatic Osteoarthritis for Future Prospects of Diagnosis: from Knee to Temporomandibular Joint
Sign Up to like & getrecommendations! Published in 2021 at "Current Osteoporosis Reports"
DOI: 10.1007/s11914-021-00661-3
Abstract: Many mechanical load-bearing joints of the body are prone to posttraumatic osteoarthritis (PTOA), including the knee joint and temporomandibular joint (TMJ). Early detection of PTOA can be beneficial in prevention or alleviating further progression of… read more here.
Keywords: early stage; temporomandibular joint; posttraumatic osteoarthritis; ptoa ... See more keywords
A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-77735-2
Abstract: Post-traumatic osteoarthritis (PTOA) is a major cause which hinders patients from the recovery after intra-articular injuries or surgeries. Currently, no effective treatment is available. In this study, we showed that inhibition of the acute stage… read more here.
Keywords: post traumatic; therapeutic agent; traumatic osteoarthritis; ptoa ... See more keywords
EphrinB2‐mediated chondrocyte autophagy induces post‐traumatic arthritis via rupture of cartilage homeostasis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.70095
Abstract: EphrinB2, a member of the Ephrin family, has been linked to several orthopaedic conditions. Nevertheless, the correlation between ephrinB2 and post‐traumatic arthritis (PTOA) remains unclear. Human PTOA cartilage from human and mouse knee joints was… read more here.
Keywords: ptoa; traumatic arthritis; cartilage; ephrinb2 ... See more keywords
Exercise-induced modulation of myokine irisin on muscle-bone unit in the rat model of post-traumatic osteoarthritis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Orthopaedic Surgery and Research"
DOI: 10.1186/s13018-024-04532-2
Abstract: Post-traumatic osteoarthritis (PTOA) is a subtype of osteoarthritis (OA). Exercise may produce and release the myokine irisin through muscle fiber contraction. However, the effect of exercise-promoted irisin production on the internal interactions of the muscle–bone… read more here.
Keywords: ptoa; muscle; irisin; bone ... See more keywords
Infectiological Outcome of Total Hip and Total Knee Arthroplasty in Post-Traumatic and Primary Osteoarthritis
Sign Up to like & getrecommendations! Published in 2024 at "Antibiotics"
DOI: 10.3390/antibiotics13121186
Abstract: Background: The objective of this study was to compare infection rates, pathogen species detection and antimicrobial susceptibility testing in patients with total hip arthroplasty (THA) and total knee arthroplasty (TKA) following post-traumatic osteoarthritis (PTOA) and… read more here.
Keywords: ptoa; total hip; tha; tka ... See more keywords
Characterization of Non-Invasively Induced Post-Traumatic Osteoarthritis in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11091783
Abstract: The pathophysiology of post-traumatic arthritis (PTOA) is not fully understood. This study used non-invasive repetitive mechanical loading (ML) mouse models to study biochemical, biomechanical, and pain-related behavioral changes induced in mice. Mouse models reflected the… read more here.
Keywords: ptoa; mouse; characterization non; mice ... See more keywords