Cryoshocked Adipocytes Mediated Dual‐Modal Strategy Combining Photodynamic Therapy and Triptolide Palmitate for Pulmonary Metastatic Melanoma Treatment
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202414307
Abstract: Pulmonary metastasis represents one of the most prevalent forms of metastasis in advanced melanoma, with mortality rates reaching 70%. Current treatments including chemotherapy, targeted therapy, and immunotherapy frequently exhibit limited efficacy or present high costs.… read more here.
Keywords: metastatic melanoma; pulmonary metastatic; therapy; ptp ... See more keywords
Chondroitin sulfate proteoglycan represses neural stem/progenitor cells migration via PTPσ/α‐actinin4 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28379
Abstract: Neural stem/progenitor cells (NSPCs) are a promising candidate for the cell‐replacement therapy after central nervous system (CNS) injury. However, the short of sufficient NSPCs migration and integration into the lesions is an essential challenge for… read more here.
Keywords: migration; stem progenitor; cspg; nspcs migration ... See more keywords
Structural characterization of a novel polysaccharide from tremella fuciformis and its interaction with gut microbiota.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.13479
Abstract: BACKGROUND Due to their diverse biological activities, polysaccharides derived from Tremella fuciformis have received growing attention. This study aimed to investigate the structural characterization of a purified polysaccharide (designated as PTP-3a) derived from Tremella fuciformis… read more here.
Keywords: ptp; gut microbiota; tremella fuciformis; structural characterization ... See more keywords
Enhanced Vanadium Redox Flow Battery Performance with New Amphoteric Ion Exchange Membranes
Sign Up to like & getrecommendations! Published in 2024 at "Macromolecular Rapid Communications"
DOI: 10.1002/marc.202400477
Abstract: Vanadium redox flow batteries (VRFBs) depend on the separator membrane for their efficiency and cycle life. Herein, two amphoteric ion exchange membranes are synthesized, based on sulfonic acid group‐grafted poly(p‐terphenyl piperidinium), for VRFBs. Using ether‐free… read more here.
Keywords: ion exchange; ptp; vanadium redox; ion ... See more keywords
Vitamin B12 Regulates Glial Migration and Synapse Formation through Isoform-Specific Control of PTP-3/LAR PRTP Expression
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.02.113
Abstract: SUMMARY Vitamin B12 is known to play critical roles during the development and aging of the brain, and vitamin B12 deficiency has been linked to neurodevelopmental and degenerative disorders. However, the underlying molecular mechanisms of… read more here.
Keywords: vitamin b12; expression; glial migration; ptp ... See more keywords
Cyclophilin D regulation of the mitochondrial permeability transition pore.
Sign Up to like & getrecommendations! Published in 2022 at "Current opinion in physiology"
DOI: 10.1016/j.cophys.2022.100486
Abstract: The opening of the mitochondrial permeability transition pore (PTP) has been proposed to play a critical role in activating cell death in many settings, including cardiac ischemia and reperfusion. Although the identity of pore forming… read more here.
Keywords: ptp; transition pore; mitochondrial permeability; permeability transition ... See more keywords
Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.103274
Abstract: Summary Internalized and ubiquitinated signaling receptors are silenced by their intraluminal budding into multivesicular bodies aided by the endosomal sorting complexes required for transport (ESCRT) machinery. HD-PTP, an ESCRT protein, forms complexes with ESCRT-0, -I… read more here.
Keywords: ptp escrt; endofin required; endosomal sorting; endofin ... See more keywords
A novel class of cardioprotective small-molecule PTP inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacological research"
DOI: 10.1016/j.phrs.2019.104548
Abstract: Ischemia/reperfusion (I/R) injury is mediated in large part by opening of the mitochondrial permeability transition pore (PTP). Consequently, inhibitors of the PTP hold great promise for the treatment of a variety of cardiovascular disorders. At… read more here.
Keywords: ptp opening; small molecule; cypd; novel class ... See more keywords
Transsynaptic modulation of presynaptic short-term plasticity in hippocampal mossy fiber synapses
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23153-5
Abstract: The hippocampal mossy fiber synapse is a key synapse of the trisynaptic circuit. Post-tetanic potentiation (PTP) is the most powerful form of plasticity at this synaptic connection. It is widely believed that mossy fiber PTP… read more here.
Keywords: fiber; hippocampal mossy; mossy fiber; ptp ... See more keywords
Dicerium letterbox-shaped tetraphenolates: f-block complexes designed for two-electron chemistry.
Sign Up to like & getrecommendations! Published in 2019 at "Dalton transactions"
DOI: 10.1039/c9dt03291f
Abstract: Rare examples of molecular, dinuclear CeIII and PrIII complexes with robust Ln-coordination are accessible by use of the tetraphenolate pTP as a supporting, chelating O-donor ligand platform, pTP = [{2-(OC6H2R2-2,4)2CH}-C6H4-1,4]4- that favours the higher formal… read more here.
Keywords: chemistry; shaped tetraphenolates; letterbox shaped; ptp ... See more keywords
Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFNγ signaling
Sign Up to like & getrecommendations! Published in 2017 at "Oncoimmunology"
DOI: 10.1080/2162402x.2017.1321185
Abstract: ABSTRACT PTP1B and TC-PTP are highly related protein-tyrosine phosphatases (PTPs) that regulate the JAK/STAT signaling cascade essential for cytokine-receptor activation in immune cells. Here, we describe a novel immunotherapy approach whereby monocyte-derived dendritic cell (moDC)… read more here.
Keywords: ptp; ptp1b ptp; immunotherapy; dendritic cell ... See more keywords