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Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800529
Abstract: A highly selective detection method of native protein tyrosine phosphatase 1B (PTP1B) is described using a target specific probe equipped with 1‐naphthylamine (λex=330 nm, λem=445 nm). Irradiation of a mixture of PTP1B and Probe 1 with ultraviolet light…
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Keywords:
detection;
probe;
tyrosine phosphatase;
protein tyrosine ... See more keywords
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Published in 2019 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-019-05771-8
Abstract: Background/Aims The purpose of this study is to explore the inhibition or activation effects of microRNA-146 B on the expression of PTP1B in gastric cancer cells. Methods The expressions of PTP1B and miR-146b in gastric…
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Keywords:
apoptosis;
gastric cancer;
ptp1b;
expression ... See more keywords
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Published in 2021 at "Molecular diversity"
DOI: 10.1007/s11030-021-10323-2
Abstract: Protein tyrosine phosphatase 1B (PTP1B) acts as a therapeutic target for type 2 diabetes. However, the major challenges of PTP1B drug discovery are the poor selectivity and the weak oral bioavailability. In this study, we…
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Keywords:
virtual screening;
tyrosine phosphatase;
combined virtual;
protein tyrosine ... See more keywords
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Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.03.075
Abstract: Protein tyrosine phosphatase 1B (PTP1B) is a widely expressed 50 kDa enzyme and the first intracellular PTP to be purified from human placental tissue. It has been proved that protein tyrosine phosphatase 1B played a significant…
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Keywords:
tyrosine phosphatase;
phosphatase ptp1b;
protein tyrosine;
ptp1b ... See more keywords
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Published in 2021 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2020.12.025
Abstract: A close relationship has been reported to exist between cadherin-mediated cell–cell adhesion and integrin-mediated cell mobility, and protein tyrosine phosphatase 1B (PTP1B) may be involved in maintaining this homeostasis. The stable residence of mesenchymal stem…
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Keywords:
bone regeneration;
tyrosine phosphatase;
protein tyrosine;
bone ... See more keywords
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Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.12.032
Abstract: Protein tyrosine phosphatase 1B (PTP1B) has been considered as a promising therapeutic target for type 2 diabetes mellitus (T2DM) and obesity due to its key regulating effects in insulin signaling and leptin receptor pathways. In…
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Keywords:
bisarylethenesulfonic acid;
stereoisomeric bisarylethenesulfonic;
acid esters;
investigation stereoisomeric ... See more keywords
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Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.01.057
Abstract: Protein tyrosine phosphatase 1B (PTP1B) has been considered as a validated biological target for type 2 diabetes treatment, but past endeavors to develop inhibitors of PTP1B into drugs have been unsuccessful. Two challenging aspects are…
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Keywords:
compound could;
ptp1b;
compound;
new series ... See more keywords
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Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.04.061
Abstract: Type 2 diabetes mellitus (DM) is a complex chronic disorder and a major global health problem. Insulin resistance is the primary detectable abnormality and the main characteristic feature in individuals with type 2 DM. Protein…
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Keywords:
tyrosine phosphatase;
study;
phosphatase ptp1b;
protein tyrosine ... See more keywords
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Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2017.03.023
Abstract: BACKGROUND Ethno-botanical information from diabetic patients in Cuba led to the identification of Allophylus cominia as a possible source of new drugs for the treatment of type 2 diabetes mellitus (T2-DM). EXPERIMENTAL Chemical characterization of…
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Keywords:
allophylus cominia;
ptp1b;
cominia;
glucosidase ... See more keywords
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Published in 2020 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2020.01.018
Abstract: Objective Non-alcoholic steatohepatitis (NASH) is characterized by a robust pro-inflammatory component at both hepatic and systemic levels together with a disease-specific gut microbiome signature. Protein tyrosine phosphatase 1 B (PTP1B) plays distinct roles in non-immune…
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Keywords:
gut;
ptp1b;
mice;
gut barrier ... See more keywords
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Published in 2021 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2021.105402
Abstract: Mutations in the beta-amyloid protein (APP) cause familial Alzheimer's disease. In hAPP-J20 mice expressing mutant APP, pharmacological inhibition or genetic ablation of the tyrosine phosphatase PTP1B prevents CA3 hippocampus neuron loss and cognitive decline. However,…
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Keywords:
alzheimer disease;
disease;
ptp1b;
mice ... See more keywords