Protein tyrosine phosphatase 1B (PTP1B) function, structure, and inhibition strategies to develop antidiabetic drugs
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DOI: 10.1002/1873-3468.14901
Abstract: Tyrosine protein phosphatase non‐receptor type 1 (PTP1B; also known as protein tyrosine phosphatase 1B) is a member of the protein tyrosine phosphatase (PTP) family and is a soluble enzyme that plays an essential role in… read more here.
Keywords: inhibition; phosphatase ptp1b; ptp1b; phosphatase ... See more keywords
Label‐Free Detection of Protein Tyrosine Phosphatase 1B (PTP1B) by Using a Rationally Designed Förster Resonance Energy Transfer (FRET) Probe
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800529
Abstract: A highly selective detection method of native protein tyrosine phosphatase 1B (PTP1B) is described using a target specific probe equipped with 1‐naphthylamine (λex=330 nm, λem=445 nm). Irradiation of a mixture of PTP1B and Probe 1 with ultraviolet light… read more here.
Keywords: detection; probe; tyrosine phosphatase; protein tyrosine ... See more keywords
Virtual and in Vitro Screening Employing a Repurposing Approach Reveal 13‐cis‐Retinoic Acid is a PTP1B Inhibitor
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DOI: 10.1002/cmdc.202400452
Abstract: Current treatments for type 2 diabetes (T2D) mainly rely on exercise, dietary control, and anti‐diabetic drugs to enhance insulin secretion and improve insulin sensitivity. However, there is a need for more therapeutic options, as approved… read more here.
Keywords: retinoic acid; repurposing approach; ptp1b; cis retinoic ... See more keywords
miR-146b Regulates Cell Proliferation and Apoptosis in Gastric Cancer by Targeting PTP1B
Sign Up to like & getrecommendations! Published in 2019 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-019-05771-8
Abstract: Background/Aims The purpose of this study is to explore the inhibition or activation effects of microRNA-146 B on the expression of PTP1B in gastric cancer cells. Methods The expressions of PTP1B and miR-146b in gastric… read more here.
Keywords: apoptosis; gastric cancer; ptp1b; expression ... See more keywords
Discovery of inhibitors targeting protein tyrosine phosphatase 1B using a combined virtual screening approach.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular diversity"
DOI: 10.1007/s11030-021-10323-2
Abstract: Protein tyrosine phosphatase 1B (PTP1B) acts as a therapeutic target for type 2 diabetes. However, the major challenges of PTP1B drug discovery are the poor selectivity and the weak oral bioavailability. In this study, we… read more here.
Keywords: virtual screening; tyrosine phosphatase; combined virtual; protein tyrosine ... See more keywords
Identification of protein tyrosine phosphatase 1B (PTP1B) inhibitors through De Novo Evoluton, synthesis, biological evaluation and molecular dynamics simulation.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.03.075
Abstract: Protein tyrosine phosphatase 1B (PTP1B) is a widely expressed 50 kDa enzyme and the first intracellular PTP to be purified from human placental tissue. It has been proved that protein tyrosine phosphatase 1B played a significant… read more here.
Keywords: tyrosine phosphatase; phosphatase ptp1b; protein tyrosine; ptp1b ... See more keywords
Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering
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DOI: 10.1016/j.bioactmat.2020.12.025
Abstract: A close relationship has been reported to exist between cadherin-mediated cell–cell adhesion and integrin-mediated cell mobility, and protein tyrosine phosphatase 1B (PTP1B) may be involved in maintaining this homeostasis. The stable residence of mesenchymal stem… read more here.
Keywords: bone regeneration; tyrosine phosphatase; protein tyrosine; bone ... See more keywords
Investigation of stereoisomeric bisarylethenesulfonic acid esters for discovering potent and selective PTP1B inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.12.032
Abstract: Protein tyrosine phosphatase 1B (PTP1B) has been considered as a promising therapeutic target for type 2 diabetes mellitus (T2DM) and obesity due to its key regulating effects in insulin signaling and leptin receptor pathways. In… read more here.
Keywords: bisarylethenesulfonic acid; stereoisomeric bisarylethenesulfonic; acid esters; investigation stereoisomeric ... See more keywords
Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.01.057
Abstract: Protein tyrosine phosphatase 1B (PTP1B) has been considered as a validated biological target for type 2 diabetes treatment, but past endeavors to develop inhibitors of PTP1B into drugs have been unsuccessful. Two challenging aspects are… read more here.
Keywords: compound could; ptp1b; compound; new series ... See more keywords
Pyrazoles as novel protein tyrosine phosphatase 1B (PTP1B) inhibitors: An in vitro and in silico study.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.04.061
Abstract: Type 2 diabetes mellitus (DM) is a complex chronic disorder and a major global health problem. Insulin resistance is the primary detectable abnormality and the main characteristic feature in individuals with type 2 DM. Protein… read more here.
Keywords: tyrosine phosphatase; study; phosphatase ptp1b; protein tyrosine ... See more keywords
In vitro anti-diabetic activity of flavonoids and pheophytins from Allophylus cominia Sw . on PTP1B, DPPIV, alpha-glucosidase and alpha-amylase enzymes.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2017.03.023
Abstract: BACKGROUND Ethno-botanical information from diabetic patients in Cuba led to the identification of Allophylus cominia as a possible source of new drugs for the treatment of type 2 diabetes mellitus (T2-DM). EXPERIMENTAL Chemical characterization of… read more here.
Keywords: allophylus cominia; ptp1b; cominia; glucosidase ... See more keywords