Carbazole alkaloids from the fruits of Clausena anisum-olens with potential PTP1B and α-glucosidase inhibitory activities.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.104775
Abstract: The phytochemical investigation on the fruits of Clausena anisum-olens led to the isolation of 18 carbazole alkaloids (1-18), containing three new ones, clausenanisines A-C (1-3), and three new naturally occurring carbazole alkaloids, clausenanisines D-F (4-6),… read more here.
Keywords: inhibitory activities; ptp1b glucosidase; anisum olens; carbazole alkaloids ... See more keywords
Effectiveness of cyclohexyl functionality in ugonins from Helminthostachys zeylanica to PTP1B and α-glucosidase inhibitions.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.10.061
Abstract: Ugonins are unique flavonoids with cyclohexyl motif from Helminthostachys zeylanica. Ugonins (1-6) from the target plant displayed significant inhibitions against both PTP1B (IC50s = 0.6-7.3 μM) and α-glucosidase (IC50s = 3.9-32.9 μM), which are crucial enzymes associated with diabetes. A cyclohexyl… read more here.
Keywords: functionality; cyclohexyl functionality; cyclohexyl motif; ptp1b glucosidase ... See more keywords
Chalcone derivatives from the root bark of Morus alba L. act as inhibitors of PTP1B and α-glucosidase.
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DOI: 10.1016/j.phytochem.2018.08.001
Abstract: As part of our continuing research to obtain pharmacologically active compounds from Morus alba L. (Moraceae), four Diels-Alder type adducts (DAs) [morusalbins A-D], one isoprenylated flavonoid [albanin T], together with twenty-one known phenolic compounds were… read more here.
Keywords: chalcone derivatives; ptp1b glucosidase; morus alba; root bark ... See more keywords