Polycyclic phloroglucinols as PTP1B inhibitors from Hypericum longistylum: Structures, PTP1B inhibitory activities, and interactions with PTP1B.
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DOI: 10.1016/j.bioorg.2017.09.001
Abstract: Protein tyrosine phosphatase 1B (PTP1B) has been regarded asa target for the research and development of new drugs to treat type II diabetes and PTP1B inhibitors are potential lead compounds for this type of new… read more here.
Keywords: ptp1b inhibitory; phloroglucinols ptp1b; ptp1b inhibitors; polycyclic phloroglucinols ... See more keywords
Docking Assisted Prediction and Biological Evaluation of Sideritis L. Components with PTP1b Inhibitory Action and Probable Anti-Diabetic Properties.
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DOI: 10.2174/1568026619666190219104430
Abstract: BACKGROUND The main characteristic of Diabetes type II is the impaired activation of intracellular mechanisms triggered by the action of insulin. PTP1b is a Protein Tyrosine Phosphatase that dephosphorylates insulin receptor causing its desensitization. Since… read more here.
Keywords: sideritis components; inhibitory action; ptp1b inhibitory; action ... See more keywords