Protein tyrosine phosphatase 4A3 (PTP4A3/PRL-3) promotes the aggressiveness of human uveal melanoma through dephosphorylation of CRMP2
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DOI: 10.1038/s41598-019-39643-y
Abstract: Uveal melanoma (UM) is an aggressive tumor in which approximately 50% of patients develop metastasis. Expression of the PTP4A3 gene, encoding a phosphatase, is predictive of poor patient survival. PTP4A3 expression in UM cells increases… read more here.
Keywords: ptp4a3; crmp2; tyrosine phosphatase; protein tyrosine ... See more keywords
The Role of Protein Tyrosine Phosphatase PTP4A3 in T-Cell Acute Lymphoblastic Leukemia Progression
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DOI: 10.1182/blood-2019-126256
Abstract: The tyrosine protein tyrosine phosphatase PTP4A3 has been extensively reported to play a causative role in numerous cancers, including several types of acute leukemia. We found PTP4A3 to be highly expressed in T-cell Acute Lymphoblastic… read more here.
Keywords: ptp4a3; phosphatase; progression; cell ... See more keywords
NSD2 Regulates Pro-Metastatic Gene PTP4A3 through Chromatin Remodeling in Multiple Myeloma
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DOI: 10.1182/blood-2020-134766
Abstract: Nuclear receptor-binding SET domain 2 (NSD2) is the primary oncogenic driver and represent a good druggable target due to its universal overexpression in t(4;14) MM. However, given the challenges in the development of small molecule… read more here.
Keywords: ptp4a3; myeloma; chromatin remodeling; nsd2 ... See more keywords