The ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy
Sign Up to like & getrecommendations! Published in 2017 at "Current Biology"
DOI: 10.1016/j.cub.2016.12.038
Abstract: Summary Mitochondria form close physical associations with the endoplasmic reticulum (ER) that regulate a number of physiological functions. One mechanism by which regions of ER are recruited to mitochondria involves binding of the ER protein… read more here.
Keywords: autophagy mitochondria; ptpip51; mitochondria tethering; vapb ptpip51 ... See more keywords
PTPIP51 regulates mouse cardiac ischemia/reperfusion through mediating the mitochondria-SR junction
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45379
Abstract: Protein tyrosine phosphatase interacting protein 51 (PTPIP51) participates in multiple cellular processes, and dysfunction of PTPIP51 is implicated in diseases such as cancer and neurodegenerative disorders. However, there is no functional evidence showing the physiological… read more here.
Keywords: ischemia reperfusion; ptpip51; heart; mitochondrial ca2 ... See more keywords
The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-019-0688-4
Abstract: Signaling between the endoplasmic reticulum (ER) and mitochondria regulates a number of key neuronal functions. This signaling involves close physical contacts between the two organelles that are mediated by “tethering proteins” that function to recruit… read more here.
Keywords: endoplasmic reticulum; ptpip51; reticulum mitochondria; activity ... See more keywords
Crosstalks of the PTPIP51 interactome revealed in Her2 amplified breast cancer cells by the novel small molecule LDC3/Dynarrestin
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DOI: 10.1371/journal.pone.0216642
Abstract: LDC3/Dynarrestin, an aminothiazole derivative, is a recently developed small molecule, which binds protein tyrosine phosphatase interacting protein 51 (PTPIP51). PTPIP51 interacts with various proteins regulating different signaling pathways leading to proliferation and migration. Her2 positive… read more here.
Keywords: ptpip51 interactome; ptpip51; small molecule; ldc3 dynarrestin ... See more keywords