Inhibiting microRNA-142-5p improves learning and memory in Alzheimer’s disease rats via targeted regulation of the PTPN1-mediated Akt pathway
Sign Up to like & getrecommendations! Published in 2022 at "Brain research bulletin"
DOI: 10.1016/j.brainresbull.2022.02.016
Abstract: OBJECTIVE MicroRNAs (miRNAs) have been recognized as possible biomarkers for Alzheimer's disease (AD). MiR-142-5p has been reported to be abnormally expressed in brain tissues. However, the role of miR-142-5p in AD pathogenesis keeps unclear. This… read more here.
Keywords: mir 142; akt pathway; learning memory; ptpn1 ... See more keywords
Skeletal myocyte-specific knockout of Ptpn1 and Ptpn2 enhances inflammatory response in muscle and increases mortality in polymicrobial sepsis
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DOI: 10.1093/eurheartj/ehae666.3696
Abstract: Critically ill patients often suffer from heart and skeletal muscle atrophy and failure (intensive care unit acquired weakness; ICUAW). Inflammation and sepsis are major risk factors for ICUAW. Critically ill patients with sepsis frequently develop… read more here.
Keywords: skeletal muscle; muscle; ptpn1; ptpn1 ptpn2 ... See more keywords
Protein tyrosine phosphatase PTPN1 modulates cell growth and associates with poor outcome in human neuroblastoma
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DOI: 10.1186/s13000-019-0919-9
Abstract: BackgroundProtein tyrosine phosphatases (PTPs) regulate neuronal differentiation and survival, but their expression patterns and functions in human neuroblastoma (NB) are scarcely known. Here, we have investigated the function and expression of the non-receptor PTPN1 on… read more here.
Keywords: cell growth; human neuroblastoma; expression; cell ... See more keywords