Stathmin levels alter PTPN14 expression and impact neuroblastoma cell migration
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DOI: 10.1038/s41416-019-0669-1
Abstract: Background Stathmin mediates cell migration and invasion in vitro, and metastasis in vivo. To investigate stathmin’s role on the metastatic process, we performed integrated mRNA–miRNA expression analysis to identify pathways regulated by stathmin. Methods MiRNA… read more here.
Keywords: cell migration; migration; expression; ptpn14 ... See more keywords
A Conserved Amino Acid in the C Terminus of Human Papillomavirus E7 Mediates Binding to PTPN14 and Repression of Epithelial Differentiation
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DOI: 10.1128/jvi.01024-20
Abstract: The E7 oncoprotein is a primary driver of HPV-mediated carcinogenesis. HPV E7 binds the putative tumor suppressor PTPN14 and targets it for degradation using the ubiquitin ligase UBR4. PTPN14 binds to a C-terminal arginine highly… read more here.
Keywords: differentiation; ptpn14 binding; life; ptpn14 ... See more keywords
MmuPV1 E7’s interaction with PTPN14 delays Epithelial differentiation and contributes to virus-induced skin disease
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1011215
Abstract: Human papillomaviruses (HPVs) contribute to approximately 5% of all human cancers. Species-specific barriers limit the ability to study HPV pathogenesis in animal models. Murine papillomavirus (MmuPV1) provides a powerful tool to study the roles of… read more here.
Keywords: induced lesions; ptpn14; epithelial differentiation; mmupv1 ... See more keywords