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   Articles with "ptpn2" as a keyword



Evaluation of MicroRNA-210 and Protein tyrosine phosphatase, non-receptor type 2 in Pre-eclampsia.

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recommendations! Published in 2017 at "Gene"

DOI: 10.1016/j.gene.2016.10.014

Abstract: BACKGROUND The precise origin of Pre-eclampsia (PE) remains elusive. Multiple pieces of evidence support the existence of hypoxia in PE. MiRNA-210 (miR-210), which is induced by Hypoxia-Inducible Factor-1α (HIF-1α) during hypoxia, is one of the… read more here.

Keywords: ptpn2; tyrosine phosphatase; protein tyrosine; pre eclampsia ... See more keywords

LOSS OF INTESTINAL EPITHELIAL PTPN2 SELECTIVELY IMPAIRS GOBLET CELL DIFFERENTIATION DURING TYPE I IMMUNITY RESPONSE

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recommendations! Published in 2025 at "Gastroenterology"

DOI: 10.1053/j.gastro.2025.01.183

Abstract: Loss-of-function variants in the Protein Tyrosine Phosphatase non-receptor Type 2 (PTPN2) gene are associated with increased risk of Inflammatory Bowel Disease (IBD). PTPN2 encodes a tyrosine phosphatase that negatively regulates signaling pathways - including JAK-STAT… read more here.

Keywords: differentiation; mice; ptpn2; cell ... See more keywords

Intestinal epithelial PTPN2 limits pathobiont colonization by immune-directed antimicrobial responses

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recommendations! Published in 2025 at "Gut Microbes"

DOI: 10.1080/19490976.2025.2559029

Abstract: ABSTRACT Loss of activity of the inflammatory bowel disease (IBD) susceptibility gene, protein tyrosine phosphatase non-receptor type 2 (PTPN2), is associated with altered microbiome composition in both human subjects and mice. Furthermore, expansion of the… read more here.

Keywords: mice; ptpn2 iec; intestinal epithelial; ptpn2 ... See more keywords

PTPN2 and Leukopenia in Individuals With Normal TPMT and NUDT15 Metabolizer Status Taking Azathioprine

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recommendations! Published in 2025 at "Clinical and Translational Science"

DOI: 10.1111/cts.70220

Abstract: Leukopenia is a common dose‐dependent side effect of azathioprine, often leading to drug discontinuation. Variants in TPMT and NUDT15 are associated with azathioprine‐induced leukopenia but only explain 25% of cases. Thus, we aimed to identify… read more here.

Keywords: individuals normal; ptpn2 leukopenia; ptpn2; leukopenia individuals ... See more keywords

PTPN2 elicits cell autonomous and non–cell autonomous effects on antitumor immunity in triple-negative breast cancer

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recommendations! Published in 2022 at "Science Advances"

DOI: 10.1126/sciadv.abk3338

Abstract: The tumor-suppressor PTPN2 is diminished in a subset of triple-negative breast cancers (TNBCs). Paradoxically, PTPN2-deficiency in tumors or T cells in mice can facilitate T cell recruitment and/or activation to promote antitumor immunity. Here, we… read more here.

Keywords: cell; cell autonomous; triple negative; ptpn2 ... See more keywords

Intestinal Epithelial Cell PTPN2 Restricts Intestinal Permeability and Tight-Junction Remodelling Caused by Adherent-invasive E. coli in Mice

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recommendations! Published in 2023 at "Physiology"

DOI: 10.1152/physiol.2023.38.s1.5734009

Abstract: Background: Alterations in epithelial tight junction proteins can compromise the ability of the intestinal mucosa to act as a barrier between luminal contents and underlying tissues. The resulting increase in intestinal permeability can give rise… read more here.

Keywords: ptpn2 iec; physiology; ptpn2; mice ... See more keywords

Myeloid Ptpn2 Deficiency in Mice Causes Functional Iron Deficiency

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recommendations! Published in 2024 at "Physiology"

DOI: 10.1152/physiol.2024.39.s1.2332

Abstract: Background: Anemia is the most prevalent extraintestinal complication of inflammatory bowel disease (IBD) and is associated with the manifestation of Crohn’s disease. Anemia significantly reduces the quality of life, increases hospitalization visits, and increases medical… read more here.

Keywords: mice; physiology; iron; ptpn2 ... See more keywords

The IBD risk gene PTPN2 maintains the spatial distribution of small intestinal antimicrobial peptides in mice

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recommendations! Published in 2025 at "Physiology"

DOI: 10.1152/physiol.2025.40.s1.1261

Abstract: Background: Defective intestinal barrier function and microbiome alterations are major contributors to the pathogenesis of inflammatory Bowel Disease (IBD), which afflicts ~3.2 million Americans. Loss-of-function SNPs within the protein tyrosine phosphatase non-receptor type 2 (PTPN2)… read more here.

Keywords: mice; ibd; physiology; ptpn2 ... See more keywords

PTPN2 Downregulation Is Associated with Albuminuria and Vitamin D Receptor Deficiency in Type 2 Diabetes Mellitus

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recommendations! Published in 2018 at "Journal of Diabetes Research"

DOI: 10.1155/2018/3984797

Abstract: Objective Inflammation plays a major role in albuminuria in type 2 diabetes mellitus (T2DM). Our previous studies have shown that the expression of vitamin D receptor (VDR) is downregulated in T2DM which is closely associated… read more here.

Keywords: vdr; ptpn2; type diabetes; expression ... See more keywords

Abstract 5607: Discovery and preclinical evaluation of a potent, orally bioavailable, highly selective, small molecule PTPN2/1 inhibitor

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recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.am2025-5607

Abstract: Protein tyrosine phosphatase non-receptor type 2 (PTPN2) is ubiquitously expressed, primarily in hematopoietic and placental cells. Critical negative regulator of the JAK-STAT pathway, PTPN2 functions to directly regulate signaling through cytokine receptors, including IFNγ. Thus,… read more here.

Keywords: ze00 0388; preclinical evaluation; ptpn2; potent orally ... See more keywords

The HIV latency reversing agent HODHBt inhibits the phosphatases PTPN1 and PTPN2

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recommendations! Published in 2024 at "JCI Insight"

DOI: 10.1172/jci.insight.179680

Abstract: Nonreceptor tyrosine phosphatases (NTPs) play an important role in regulating protein phosphorylation and have been proposed as attractive therapeutic targets for cancer and metabolic diseases. We have previously identified that 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one (HODHBt) enhanced STAT activation… read more here.

Keywords: ptpn2; ptpn1 ptpn2; hodhbt; hiv latency ... See more keywords