PTPN21‐CDSlong isoform inhibits the response of acute lymphoblastic leukemia cells to NK‐mediated lysis via the KIR/HLA‐I axis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29601
Abstract: Protein tyrosine phosphatase non‐receptor type 21 (PTPN21) is a member of the non‐receptor tyrosine phosphatase family. We have found that PTPN21 is mutated in relapsed Philadelphia chromosome‐negative acute lymphoblastic leukemia (ALL) after allogeneic hematopoietic stem… read more here.
Keywords: ptpn21; isoform; lymphoblastic leukemia; cells mediated ... See more keywords
Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.
Sign Up to like & getrecommendations! Published in 2019 at "Cell stem cell"
DOI: 10.1016/j.stem.2019.02.009
Abstract: Hematopoietic stem cell (HSC) quiescence is a tightly regulated process crucial for hematopoietic regeneration, which requires a healthy and supportive microenvironmental niche within the bone marrow (BM). Here, we show that deletion of Ptpn21, a… read more here.
Keywords: ptpn21; biomechanics; stem cell; hematopoietic stem ... See more keywords
Decreased cell stiffness enhances leukemia development and progression
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DOI: 10.1038/s41375-020-0763-7
Abstract: Emerging evidence has linked cell mechanics to functional behaviors [1]. The biophysical traits of a single cell are inextricably linked to the cytoskeleton. It has become increasingly evident that intrinsic and extrinsic mechanical properties, which… read more here.
Keywords: cell; ptpn21; mice; mll af9 ... See more keywords