C1858T Polymorphism of Protein Tyrosine Phosphatase Non-receptor Type 22 (PTPN22): an eligible target for prevention of type 1 diabetes?
Sign Up to like & getrecommendations! Published in 2017 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2017.1266257
Abstract: ABSTRACT Introduction: In type 1 diabetes (T1D), several genetic factors are associated to β-cell autoimmunity onset and clinical progression. HLA-genes play a major role in susceptibility and initiation of β-cell autoimmunity, whereas non-HLA genes may… read more here.
Keywords: ptpn22; tyrosine phosphatase; target; type diabetes ... See more keywords
Region 1p13.2 including the RSBN1, PTPN22, AP4B1 and long non‐coding RNA genes does not bear risk factors for endemic pemphigus foliaceus (fogo selvagem)
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Immunogenetics"
DOI: 10.1111/iji.12423
Abstract: Pemphigus foliaceus (PF) is an autoimmune skin disease characterized by autoantibodies directed mainly against desmoglein‐1. The purpose of this study was to determine whether differential susceptibility to endemic PF in Brazil (fogo selvagem) is associated… read more here.
Keywords: ptpn22; long non; pemphigus foliaceus; rsbn1 ptpn22 ... See more keywords
TiO2 nanoparticles abrogate the protective effect of the Crohn’s disease-associated variation within the PTPN22 gene locus
Sign Up to like & getrecommendations! Published in 2022 at "Gut"
DOI: 10.1136/gutjnl-2021-325911
Abstract: Objective Inflammatory bowel disease (IBD) is a multifactorial condition driven by genetic and environmental risk factors. A genetic variation in the protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene has been associated with autoimmune disorders… read more here.
Keywords: effect; disease; ptpn22; tio2 nanoparticles ... See more keywords
Protein tyrosine phosphatase PTPN22 negatively modulates platelet function and thrombus formation.
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DOI: 10.1182/blood.2022015554
Abstract: Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a protein tyrosine phosphatase and negatively regulates T cell signaling. However, whether it is expressed and functions in platelets remains unknown. Here we investigated the expression and… read more here.
Keywords: protein tyrosine; phosphatase; tyrosine phosphatase; ptpn22 ... See more keywords
Improvement of Lipoplexes With a Sialic Acid Mimetic to Target the C1858T PTPN22 Variant for Immunotherapy in Endocrine Autoimmunity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.838331
Abstract: The C1858T variant of the protein tyrosine phosphatase N22 (PTPN22) gene is associated with pathophysiological phenotypes in several autoimmune conditions, namely, Type 1 diabetes and autoimmune thyroiditis. The R620W variant protein, encoded by C1858T, leads… read more here.
Keywords: c1858t ptpn22; liposirna sig10l; ptpn22; c1858t ... See more keywords
Analysis of PTPN22 −1123 G>C, +788 G>A and +1858 C>T Polymorphisms in Patients with Primary Sjögren’s Syndrome
Sign Up to like & getrecommendations! Published in 2023 at "Diagnostics"
DOI: 10.3390/diagnostics13050899
Abstract: Background: Primary Sjögren’s syndrome (pSS) is an autoimmune exocrinopathy characterized by lymphocytic infiltration, glandular dysfunction and systemic manifestations. Lyp protein is a negative regulator of the T cell receptor encoded by the tyrosine phosphatase nonreceptor-type… read more here.
Keywords: primary gren; gren syndrome; ptpn22; expression ... See more keywords
UBASH3A Interacts with PTPN22 to Regulate IL2 Expression and Risk for Type 1 Diabetes
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24108671
Abstract: UBASH3A is a negative regulator of T cell activation and IL-2 production and plays key roles in autoimmunity. Although previous studies revealed the individual effects of UBASH3A on risk for type 1 diabetes (T1D; a… read more here.
Keywords: risk type; ptpn22; t1d; risk ... See more keywords
Genetic Polymorphism of PTPN22 in Autoimmune Diseases: A Comprehensive Review
Sign Up to like & getrecommendations! Published in 2022 at "Medicina"
DOI: 10.3390/medicina58081034
Abstract: It is known that the etiology and clinical outcomes of autoimmune diseases are associated with a combination of genetic and environmental factors. In the case of the genetic factor, the SNPs of the PTPN22 gene… read more here.
Keywords: genetic polymorphism; etiology; autoimmune diseases; ptpn22 ... See more keywords
PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.81577
Abstract: A genetic variant in the gene PTPN22 (R620W, rs2476601) is strongly associated with increased risk for multiple autoimmune diseases and has been linked to altered TCR regulation. Here, we utilize Crispr/Cas9 gene editing with donor… read more here.
Keywords: tcr; ptpn22; risk; ptpn22 r620w ... See more keywords