Lactylation-Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22-Mediated Dephosphorylation of NLRP3.
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DOI: 10.1002/advs.202510192
Abstract: Metabolic dysfunction-associated steatotic liver disease (MASLD) is among the most prevalent chronic liver diseases worldwide. The expression of YTH domain-containing protein 1 (YTHDC1) is significantly reduced in patients and mouse models with MASLD. Hepatocyte-specific knockout… read more here.
Keywords: mediated dephosphorylation; alleviates masld; lactylation; ptpn22 mediated ... See more keywords