PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses
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DOI: 10.7554/elife.81577
Abstract: A genetic variant in the gene PTPN22 (R620W, rs2476601) is strongly associated with increased risk for multiple autoimmune diseases and has been linked to altered TCR regulation. Here, we utilize Crispr/Cas9 gene editing with donor… read more here.
Keywords: tcr; ptpn22; risk; ptpn22 r620w ... See more keywords