IL-6 induces tumor suppressor protein tyrosine phosphatase receptor type D by inhibiting miR-34a to prevent IL-6 signaling overactivation
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-020-03803-w
Abstract: Protein tyrosine phosphatase receptor type D (PTPRD) is a tumor suppressor gene that is epigenetically silenced and mutated in several cancers, including breast cancer. Since IL-6/STAT3 signaling is often hyperactivated in breast cancer and STAT3… read more here.
Keywords: tumor suppressor; ptprd; mir 34a; breast cancer ... See more keywords
Methylation-mediated silencing of PTPRD induces pulmonary hypertension by promoting pulmonary arterial smooth muscle cell migration via the PDGFRB/PLCĪ³1 axis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000003220
Abstract: Objective: Pulmonary hypertension is a lethal disease characterized by pulmonary vascular remodeling and is mediated by abnormal proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs). Platelet-derived growth factor BB (PDGF-BB) is the most… read more here.
Keywords: cell; pulmonary hypertension; hypertension; ptprd ... See more keywords
Protein tyrosine phosphatase receptor type delta (PTPRD) gene in an animal model of restless legs syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Sleep Research"
DOI: 10.1111/jsr.13716
Abstract: The pathophysiology of the restless legs syndrome (RLS) is related to dopaminergic dysfunction, reduced iron and variations in gene expression, such as the protein tyrosine phosphatase receptor type delta gene (PTPRD). Animal models could be… read more here.
Keywords: ptprd; animal model; type; receptor ... See more keywords
Protein Tyrosine Phosphatase Receptor Type D Regulates Neuropathic Pain After Nerve Injury via the STING-IFN-I Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.859166
Abstract: Neuropathic pain is usually caused by injury or dysfunction of the somatosensory system, and medicine is a common way of treatment. Currently, there are still no satisfactory drugs, like opioids and lidocaine, which carry a… read more here.
Keywords: protein tyrosine; ptprd; tyrosine phosphatase; neuropathic pain ... See more keywords