Acasunlimab (DuoBody-PD-L1x4-1BB) alone or in combination with pembrolizumab (pembro) in patients (pts) with previously treated metastatic non-small cell lung cancer (mNSCLC): Initial results of a randomized, open-label, phase 2 trial.
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DOI: 10.1200/jco.2024.42.16_suppl.2533
Abstract: 2533 Background: Most pts with mNSCLC without actionable gene alterations have limited options after progression on first-line checkpoint inhibitor (CPI)–containing treatment (tx). Given failures of recent trials in this setting, single-agent chemotherapy remains the main… read more here.
Keywords: combo; trial; pts mnsclc; pembro ... See more keywords
Five-year outcomes with first-line (1L) nivolumab + ipilimumab + chemotherapy (N + I + C) vs C in patients (pts) with metastatic NSCLC (mNSCLC) in CheckMate 9LA.
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DOI: 10.1200/jco.2024.42.16_suppl.8560
Abstract: 8560 Background: InCheckMate 9LA (NCT03215706), 1L N + I + C demonstrated long-term, durable survival benefit vs C alone in pts with mNSCLC, regardless of tumor PD-L1 expression or histology. Here, we report updated efficacy… read more here.
Keywords: pts mnsclc; histology; tfi; tumor ... See more keywords