Involvement of histone deacetylase 1/2 in adrenocorticotropic hormone synthesis and proliferation of corticotroph tumor AtT-20 cells
Sign Up to like & getrecommendations! Published in 2021 at "Peptides"
DOI: 10.1016/j.peptides.2020.170441
Abstract: Cushing's disease is mainly caused by autonomous production of adrenocorticotropic hormone (ACTH) from pituitary adenomas. In our previous study, a histone deacetylase (HDAC) inhibitor, trichostatin A, inhibited cell proliferation and ACTH production via decreased pituitary… read more here.
Keywords: cell proliferation; mrna levels; proliferation; pttg1 ... See more keywords
aarF domain containing kinase 5 gene promotes invasion and migration of lung cancer cells through ADCK5-SOX9-PTTG1 pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.112002
Abstract: AarF domain containing kinase 5 (ADCK5) is a member of an atypical kinase family and overexpressed in many carcinomas including lung cancer, while the function of this protein has not been elucidated. Here we investigated… read more here.
Keywords: kinase; lung cancer; pttg1; cancer cells ... See more keywords
ECT2/PSMD14/PTTG1 axis promotes the proliferation of glioma through stabilizing E2F1
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noy207
Abstract: BACKGROUND Epithelial cell transformation sequence 2 (ECT2) is upregulated in glioma and promotes glioma cell proliferation. A preliminary experiment showed a positive correlation between ECT2 and pituitary tumor-transforming gene 1 (PTTG1). The aim of this… read more here.
Keywords: glioma; psmd14; proliferation; ect2 ... See more keywords
PTTG1 reprograms asparagine metabolism to promote hepatocellular carcinoma progression.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-3561
Abstract: Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has a poor prognosis. Pituitary tumor transforming gene 1 (PTTG1) is highly expressed in HCC, suggesting it could play an important role… read more here.
Keywords: hepatocellular carcinoma; pttg1; progression; hcc ... See more keywords
PTTG1 cooperated with GLI1 leads to epithelial-mesenchymal transition in esophageal squamous cell cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.21343
Abstract: Pituitary tumor-transforming gene-1 (PTTG1) could acquire its metastasis-promoting effects via inducing epithelial-mesenchymal transition (EMT). However, its role and mechanism in EMT in esophageal squamous cell cancer (ESCC) had not been clearly elucidated. Here, we demonstrated… read more here.
Keywords: mesenchymal transition; cell; squamous cell; pttg1 ... See more keywords
Inflammation regulates long non-coding RNA-PTTG1-1:1 in myeloid leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Haematologica"
DOI: 10.3324/haematol.2019.217281
Abstract: Elevated tumor necrosis factor (TNF) α serum levels constitute an adverse prognostic factor for the survival of acute myeloid leukemia (AML) patients. TNFα is produced by various immune effectors and directly or indirectly acts as… read more here.
Keywords: myeloid leukemia; long non; non coding; pttg1 ... See more keywords
Gene Expression Pattern of ESPL1, PTTG1 and PTTG1IP Can Potentially Predict Response to TKI First-Line Treatment of Patients with Newly Diagnosed CML
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15092652
Abstract: Simple Summary There is still a lack of reliable molecular predictors to achieve major molecular response (MMR, BCR::ABL1 ≤ 0.1% IS) within the first year of treatment with tyrosine kinase inhibitors (TKI) in the therapeutic… read more here.
Keywords: pttg1ip; pttg1; espl1 pttg1; expression ... See more keywords