Regulation of cardiac transcription by thyroid hormone and Med13.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.01.007
Abstract: Thyroid hormone (TH) is a key regulator of transcriptional homeostasis in the heart. While hypothyroidism is known to result in adverse cardiac effects, the molecular mechanisms that modulate TH signaling are not completely understood. Mediator… read more here.
Keywords: transcription; response; med13; ptu ... See more keywords
Effects of PPAR-γ agonist, pioglitazone on brain tissues oxidative damage and learning and memory impairment in juvenile hypothyroid rats
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Neuroscience"
DOI: 10.1080/00207454.2019.1632843
Abstract: Abstract Aim: The effect of peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist pioglitazone on the brain tissues oxidative damage and learning and memory impairment in the juvenile hypothyroid rats was evaluated. Main methods: Rats were classified as:… read more here.
Keywords: brain tissues; ptu; ppar agonist; agonist pioglitazone ... See more keywords
Cardiovascular protective effect of nano selenium in hypothyroid rats: protection against oxidative stress and cardiac fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Hypertension"
DOI: 10.1080/10641963.2022.2036994
Abstract: ABSTRACT Background Nano selenium (Nano Sel) has many therapeutic properties including antioxidant, anticancer, and anti-inflammatory actions. Objective Impacts of Nano Sel administration against cardiac fibrosis and heart and aorta tissue oxidative damage observed in hypothyroid… read more here.
Keywords: nano sel; ptu; fibrosis; cardiac fibrosis ... See more keywords
Cardiovascular protective effects of PPARγ agonists in hypothyroid rats: protection against oxidative stress
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Hypertension"
DOI: 10.1080/10641963.2022.2079669
Abstract: ABSTRACT Hypothyroidism disturbs redox homeostasis and takes part in cardiovascular system dysfunction. Considering antioxidant and cardio-protective effects of PPAR-γ agonists including pioglitazone (POG) and rosiglitazone (RSG), the present study was aimed to determine the effect… read more here.
Keywords: rsg; pog; heart aorta; ptu ... See more keywords
A case report dysregulated neutrophil extracellular traps in a patient with propylthiouracil-induced anti-neutrophil cytoplasmic antibody-associated vasculitis
Sign Up to like & getrecommendations! Published in 2019 at "Medicine"
DOI: 10.1097/md.0000000000015328
Abstract: Rationale: Neutrophil extracellular traps (NETs) are immune defence systems that release extracellular chromatin and myeloid granules including myeloperoxidase (MPO) to kill pathogens. An experimental animal study recently demonstrated that disordered NETs induced by propylthiouracil (PTU)… read more here.
Keywords: neutrophil cytoplasmic; cytoplasmic antibody; neutrophil extracellular; ptu ... See more keywords
Lack of preventive effect of maternal exposure to α-glycosyl isoquercitrin and α-lipoic acid on developmental hypothyroidism-induced aberrations of hippocampal neurogenesis in rat offspring
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Toxicologic Pathology"
DOI: 10.1293/tox.2019-0018
Abstract: Hypothyroidism during the developmental stage induces disruption of hippocampal neurogenesis in later life, as well as inducing oxidative stress in the brain. The present study investigated the preventive effect of co-exposure to an antioxidant on… read more here.
Keywords: hypothyroidism; preventive effect; hippocampal neurogenesis; exposure ... See more keywords
Nano‐selenium relieved hepatic and renal oxidative damage in hypothyroid rats
Sign Up to like & getrecommendations! Published in 2023 at "Physiological Reports"
DOI: 10.14814/phy2.15682
Abstract: Hypothyroidism can induce oxidative stress. Nano‐selenium (Nano Sel) has antioxidant effects. The current research explored Nano Sel effects on hepatic and renal oxidative damage induced by hypothyroidism in rats. Animals were grouped into (1) Control;… read more here.
Keywords: hypothyroidism; damage; sel; nano sel ... See more keywords
Neuroprotective effects of thymoquinone against cerebellar histopathological changes in propylthiouracilinduced hypothyroidism in adult rats
Sign Up to like & getrecommendations! Published in 2017 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v16i5.9
Abstract: Purpose: To evaluate the effects of thymoquinone (TQ) on histological and immunohistochemical changes in the cerebellar cortex induced by propylthiouracil (PTU) treatment in rats. Methods: Thirty-two adult male albino rats were randomly divided into four… read more here.
Keywords: hypothyroidism; effects thymoquinone; adult; histopathological changes ... See more keywords