Spinal microglial M1 polarization contributes paclitaxel‐induced neuropathic pain by triggering cells necroptosis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23669
Abstract: Paclitaxel (PTX) is a chemotherapeutic agent that is widely used for the treatment of several types of tumors. However, PTX‐induced peripheral neuropathy (PIPN) is an adverse effect generally induced by long‐term PTX use that significantly… read more here.
Keywords: ptx induced; microglial polarization; necroptosis; neuropathic pain ... See more keywords
Spinal blockage of CXCL1 and its receptor CXCR2 inhibits paclitaxel-induced peripheral neuropathy in mice
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.04.014
Abstract: ABSTRACT Painful peripheral neuropathy is the most dose‐limiting side effect of paclitaxel (PTX), a widely used anti‐cancer drug to treat solid tumours. The understanding of the mechanisms involved in this side effect is crucial to… read more here.
Keywords: ptx induced; cxcl1; cxcr2; spinal blockage ... See more keywords