Hydrotropic polymer-based paclitaxel-loaded self-assembled nanoparticles: preparation and biological evaluation
Sign Up to like & getrecommendations! Published in 2017 at "RSC Advances"
DOI: 10.1039/c7ra04563h
Abstract: The poor compatibility of carrier materials with drugs is one of the main obstacles in the drug encapsulation of nano-drug delivery system (NDDS), hindering the clinical translation of NDDS. In this study, using paclitaxel (PTX)… read more here.
Keywords: dena; ptx; ptx nps; pgg dena ... See more keywords
Preparation, characterization and in vitro anticancer activity of paclitaxel conjugated magnetic nanoparticles
Sign Up to like & getrecommendations! Published in 2018 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2018.1508222
Abstract: Abstract In this study, magnetic nanoparticles (MNPs) coated with L-aspartic acid (F-Asp NPs) were synthesized through a co-precipitation method and conjugated with paclitaxel (PTX) (F-Asp-PTX NPs) by esterification reaction between the carboxylic acid end groups… read more here.
Keywords: magnetic nanoparticles; ptx; ptx nps; preparation characterization ... See more keywords
In vivo synergistic anti-tumor effect of paclitaxel nanoparticles combined with radiotherapy on human cervical carcinoma
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DOI: 10.1080/10717544.2016.1230902
Abstract: Abstract In this study, our purpose was to explore the synergistic anti-tumor effect and mechanism of paclitaxel nanoparticles (PTX-NPs) combined with radiotherapy (RT) on human cervical carcinoma (HeLa). PTX-NPs were prepared by a solid dispersion… read more here.
Keywords: synergistic anti; ptx nps; effect; anti tumor ... See more keywords
The synergistic antitumor activity of 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs) and anti-PD-L1 antibody inducing immunogenic cell death
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DOI: 10.1080/10717544.2021.1909180
Abstract: Abstract Cancer immunotherapy is a strategy that is moving to the frontier of cancer treatment in the current decade. In this study, we show evidence that 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs), act as immunogenic… read more here.
Keywords: synergistic antitumor; nppa ptx; ptx nps; antitumor activity ... See more keywords
Chronic chemotherapy with paclitaxel nanoparticles induced apoptosis in lung cancer in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s188049
Abstract: Aim Paclitaxel (PTX) is an effective antitumor drug. Previous research demonstrated that paclitaxel nanoparticles (PTX-NPs) exhibited the greatest antitumor effect at 15 hours after light onset (15 HALO), but the mechanism in chronic chemotherapy is… read more here.
Keywords: ptx nps; chronic chemotherapy; apoptosis; vivo ... See more keywords
Bacteria-Driven Tumor Microenvironment-Sensitive Nanoparticles Targeting Hypoxic Regions Enhances the Chemotherapy Outcome of Lung Cancer
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DOI: 10.2147/ijn.s396863
Abstract: Background Chemotherapy still plays a dominant role in cancer treatment. However, the inability of conventional chemotherapeutic drugs to reach the hypoxic zone of solid tumors significantly weakens their efficacy. Bacteria-mediated drug delivery systems can be… read more here.
Keywords: hypoxic regions; ptx nps; bif; cancer ... See more keywords
Paclitaxel Nanoparticles Induce Apoptosis and Regulate TXR1, CYP3A4 and CYP2C8 in Breast Cancer and Hepatoma Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520620666200504071530
Abstract: BACKGROUND AND OBJECTIVE Although the anticancer potentials of water insoluble drugs are improved by nanoformulation, other intervening factors may contribute in the drug efficacy. This work was designated to explore the effect of paclitaxel-loaded poly… read more here.
Keywords: apoptosis; hepatoma cells; ptx nps; breast cancer ... See more keywords